Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins /: selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins. (2016)

• Record Type: Book
• Further Information: Note: Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors.
• Editors: Lin, Jianchang, 1983-; Wang, Bushi; Hu, Xiaowen; Chen, Kun; Liu, Ray H
• Other Names: International Chinese Statistical Association., Applied Statistics Symposium, (24th) 2015 (Fort Collins, Colo.); Graybill Conference, 13th
• Contents: Preface; Contents; Contributors; Part I Biomarker and Personalized Medicine; Optimal Biomarker-Guided Design for Targeted Therapy with Imperfectly Measured Biomarkers; 1 Introduction; 2 Methods; 2.1 Optimal Allocation Rules; 2.2 Likelihood Ratio Test Based on EM Algorithm; 3 Simulation Studies; 4 Conclusion; Appendix; Proof of Theorem 1; Proof of Theorem 2; References; Statistical Considerations for Evaluating Prognostic Biomarkers: Choosing Optimal Threshold; 1 Introduction; 2 A Brief Review of the ROC Curve; 3 Criteria Based on the ROC Curve; 4 Issues When Reporting the Optimal Threshold. 5 Simulation Study; 6 Discussion; References; Accuracy of Meta-Analysis Using Different Levels of Diagnostic Accuracy Measures; 1 Introduction; 2 Methods; 2.1 Definitions of Diagnostic Accuracy Measures; 2.2 A Bivariate Normal Model for Data Generation for Simulation Studies; 2.3 Meta-Analysis for Level 1 Data; 2.4 Meta-Analysis for Level 2 Data; 2.5 Meta-Analysis for Level 3 Data; 2.6 Simulation Experiments; 3 Simulation Results; 4 Discussion; References; Part II Bayesian Methods and Applications; Bayesian Frailty Models for Multi-State Survival Data; 1 Introduction; 2 BMT Data; 3 Models. 3.1 Model for Immediate Child States; 3.2 Models for the Gap Times with Path Specific Frailty; 3.3 Likelihood Function; 3.4 Path Probability; 3.5 Relapse Free Probability; 4 Bayesian Inference; 4.1 Prior and Posterior Distributions; 4.2 Bayesian Computations and Model Comparison; 5 Analysis of the BMT Data; 6 Discussion; References; Bayesian Integration of In Vitro Biomarker to Analysis of In Vivo Safety Assessment; 1 Introduction; 2 Methods; 2.1 In Vivo Telemetry Study; 2.2 Statistical Analysis Method; 2.3 The Bayesian Model; 2.4 Posterior Inference; 3 Analysis and Results; 4 Discussion. Part III Dose Ranging Studies in Clinical Trials; Sample Size Allocation in a Dose-Ranging Trial Combined with PoC; 1 Background; 2 Number of Doses and Control Groups; 3 Was the Concept Proven?; 4 Comparison of Power; 4.1 Four-Arm Study; 4.2 Five-Arm Study; 5 Discussion; References; Personalized Effective Dose Selection in Dose Ranging Studies; 1 Introduction; 2 Methods; 2.1 Context, Notation and Model; 2.2 Estimation: The INIA Method; 3 Numerical Examples; 3.1 Examples and Evaluation Criteria; 3.2 Single Marker Examples; 3.3 A Two-Marker Example; 3.4 A Multi-Marker Example; 4 Discussion.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (xv, 359 pages), illustrations (some color)
• Subjects: 519.5; Statistics; Mathematical statistics -- Congresses; Mathematical statistics; Statistical methods; Computer science; MATHEMATICS -- Applied; MATHEMATICS -- Probability & Statistics -- General; Mathematical statistics; Science -- Life Sciences -- General; Computers -- Mathematical & Statistical Software; Probability & statistics; Life sciences: general issues; Maths for computer scientists; Medical -- Biostatistics; Electronic books; Conference papers and proceedings
• Languages: English
• ISBNs: 9783319425689; 3319425684; 3319425676; 9783319425672
• Related ISBNs: 9783319425672
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed November 29, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.