Inflammation-associated depression : evidence, mechanisms and implications /: evidence, mechanisms and implications. (2017)

• Record Type: Book
• Further Information: Note: Robert Dantzer, Lucile Capuron, editors.
• Other Names: Dantzer, Robert; Capuron, Lucile
• Contents: Preface; Contents; Evidence for Inflammation-Associated Depression; 1 Introduction; 2 Evidence from Animal Models; 3 Evidence from Clinical Studies; 3.1 Cytokines and Cell-Mediated Immune (CMI) Pathways Contribute to Inflammation and Depression; 3.2 Platelet-Activating Factors (PAFs) and Oxidative and Nitrosative Stress (OandNS) Contribute to Inflammation and Depression; 3.3 Damage to Mitochondria and Mitochondrial DNA Contribute to Inflammation and Depression; 4 Discussion; 5 Conclusion; References. Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms1 Inflammation and Neuropsychiatric Symptoms; 1.1 From Sickness to Neuropsychiatric Disorders; 1.2 Towards the Identification of Common Major Symptom Domains Targeted by Inflammatory Processes; 1.3 Evidence for a Role of Inflammation in Distinct Neuropsychiatric Domains; 2 Inflammation and the Specificity of Neuropsychiatric Symptoms Units; 2.1 A Multimodal Biological Substrate; 2.2 Vulnerability and Modulatory Factors; The HPA Axis and Its Relation to Stress; Metabolic Abnormalities. Personality3 Conclusion and Therapeutic Implications; References; Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease; 1 Introduction; 2 Epidemiology; 2.1 Depressive Illness; 2.2 Cardiovascular Disease; 2.3 Co-morbidity Between DI and Cardiovascular Disease; 3 Factors Accountable for the Co-morbidity; 3.1 Role of Stress in Inflammation and Depression; 3.2 Autonomic Nervous System Dysfunction; 3.3 Heart Rate Variability; 4 Bidirectionality of Inflammation in Cardiovascular Disease and Depression; 4.1 Inflammation and Depression. 4.2 Inflammation and Cardiovascular Disease4.3 C-Reactive Protein; 4.4 Endothelial Dysfunction; 5 The Tryptophan/Kynurenine Pathway: Implications for Serotonergic Transmission; 6 Inflammation and the Serotonin Transporter; 7 The Glutamatergic Theory of Depression; 8 Other Mechanisms; 9 Treatment Issues; 10 Concluding Remarks; References; Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression; 1 Periphery-to-Brain Communication Pathways; 1.1 Neural Pathway; 1.2 Signaling via Cerebral Endothelial Cells; 1.3 Signaling via the Circumventricular Organs. 1.4 Peripheral Immune-Cell-to-Brain Signaling2 Changes in Brain Function as a Result of Periphery-to-Brain Communication; 3 Gut Microbiome, Systemic Inflammation, and Altered Behavior and Mood; 3.1 Gut Microbiome and Changes During Inflammatory Diseases; 3.2 Gut-to-Brain Communication Can Modulate Behavior; 3.3 Changes in Gut Microbiome Can Modulate Systemic Inflammation and Thereby Behavior; 3.4 Gut Dysbiosis in Systemic Disease; 4 Concluding Remarks; References; Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms; 1 Introduction.
• Publisher Details: Place of publication not identified : Springer
• Publication Date: 2017
• Extent: 1 online resource (x, 356 pages), illustrations
• Subjects: 616.85/27; 610; Medicine; Depression, Mental; Inflammation; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Depression, Mental; Inflammation; Depressive Disorder -- physiopathology; Medical -- Psychiatry -- Psychopharmacology; Medical -- Immunology; Psychology -- Applied Psychology; Psychopharmacology; Immunology; Health psychology; Neurosciences; Psychopharmacology; Immunology; Psychology, clinical; Medical -- Neuroscience; Neurosciences; Electronic books
• Languages: English
• ISBNs: 9783319511528; 3319511521
• Related ISBNs: 9783319511511; 3319511513
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.