Heart genomics. (2018)

• Record Type: Book
• Further Information: Note: Hong Jiang, Ming Liu, editors.
• Editors: Jiang, Hong; Liu, Ming
• Contents: Intro; Contents; Chapter 1: Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases; 1 Introduction; 2 GWAS Significant Loci; 2.1 Blood Pressure; 2.2 Coronary Artery Disease (CAD); 3 Clinical Implications; 3.1 Hypertension; 3.2 CAD; 4 Perspectives; References; Chapter 2: Cardiac Transcriptome Profile in Heart Diseases; 1 Introduction; 2 Technology Platforms; 2.1 Methods for Cardiac Transcriptome; 2.1.1 RNA Sequencing; 2.1.2 Microarray Analysis; 2.1.3 Array RT-qPCR; 2.1.4 Evaluation and Comparison; 2.2 Analysis of Transcriptome Data 2.2.1 De Novo Transcriptome Analysis2.2.2 Transcriptome Analysis with Reference Genome; 2.3 Intact Hearts vs. Isolated Cells in Cardiac Disease Studies; 3 Developmental Transcriptome Profiles of Cardiac Cells; 3.1 Developmental Transcriptional Profiles of Cardiomyocytes; 3.1.1 The Developmental Spatial Transcriptomes of CMs; 3.1.2 The Developmental Temporal Transcriptomes of CMs; 3.1.3 The Noncoding RNAs in CMs; 3.2 Developmental Transcriptional Profiles of Endothelial Cells; 3.2.1 The Developmental Temporal Transcriptomes of ECs; 3.2.2 The Function-Related Gene Expression in ECs 3.2.3 Gene Expression in ECs that Participate in the Pathogenesis of Atherosclerosis3.2.4 The Noncoding RNAs in ECs; 3.3 Developmental Transcriptional Profiles of Fibroblasts; 3.3.1 The Function-Related Gene Expression in CFs; 3.3.2 The Noncoding RNAs in CFs; 4 Transcriptomics-Based Biomarkers in Typical Heart Disease; 4.1 Coronary Artery Disease (CAD); 4.1.1 Traditional Biomarkers of MI; 4.1.2 Message RNAs Implicated in the Prediction and Detection of MI; 4.1.3 MiRNAs and LncRNAs as Diagnostic Tools in CAD; 4.2 Congestive Heart Failure; 4.2.1 Blood-Based Biomarkers in CHF 4.2.2 Expression Profiling of Human Cardiac Tissues in CHF4.2.3 CHF Related Noncoding RNAs; 4.3 Congenital Heart Disease; 4.3.1 Expression Profiling of CHD; 4.3.2 MicroRNAs in CHD; References; Chapter 3: The Emerging Role of Epigenetics; 1 Introduction; 1.1 Cardiovascular Diseases; 1.2 Epigenetics; 1.3 DNA Methylation; 1.4 Histone Modifications; 1.5 Noncoding RNAs; 2 Epigenetics and Diseases; 2.1 DNA Methylation and Diseases; 2.1.1 DNA Methylation and Cancer; 2.1.2 DNA Methylation and Atherosclerosis; 2.1.3 DNA Methylation with Cardiovascular Risk and Diseases 2.2 Histone Modification with CVDs2.2.1 Histone Modification with Hypoxia and Shear Stress; 2.2.2 Histone Modifications with CAD; 2.2.3 Histone Modifications and HF; 2.2.4 Histone Modifications with Hypertension and Pulmonary Arterial Hypertension (PAH); 2.3 RNA Silencing with CVDs; 2.3.1 miRNAs and Cardiac Aging; 2.3.2 miRNAs and HF; 2.3.3 miRNAs as Potential Biomarkers; 3 The Environment, Epigenetics, and CVD Risk; 3.1 Natural Environmental Exposures; 3.2 Personal Environment; 4 Technical Overview of Platform Used in Epigenetic Study
• Publisher Details: Singapore : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.1/2; Medicine; Heart -- Diseases -- Genetic aspects; Genomics -- Research; Medical genetics; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Cardiology; Medical research; Cardiovascular medicine; Human genetics; Cardiology; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9789811314292; 9811314292
• Related ISBNs: 9789811314285; 9811314284
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed October 16, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.