Voltage-gated sodium channels : structure, function and channelopathies /: structure, function and channelopathies. ([2018])

• Record Type: Book
• Further Information: Note: Mohamed Chahine, editor.
• Editors: Chahine, Mohamed
• Contents: Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. -- Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Extent: 1 online resource (x, 450 pages), illustrations (chiefly color)
• Subjects: 615; Medicine; Sodium channels; Toxicology; Human genetics; Human physiology; Biochemistry; Voltage-Gated Sodium Channels; Sodium Channels -- physiology; Channelopathies -- physiopathology; Human genetics; Human physiology; Medicine; Pharmacology; Proteins; Medical -- Genetics; Medical -- Physiology; Science -- Life Sciences -- Biochemistry; Medical genetics; Physiology; Proteins; Medical -- Pharmacology; Pharmacology; Biomedicine; Pharmacology/Toxicology; Human Genetics; Human Physiology; Protein Structure
• Languages: English
• ISBNs: 9783319902845; 3319902849; 3319902830; 9783319902838
• Related ISBNs: 3319902830; 9783319902838
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.