Gene therapy in reconstructive and regenerative surgery. (2018)
- Record Type:
- Book
- Title:
- Gene therapy in reconstructive and regenerative surgery. (2018)
- Main Title:
- Gene therapy in reconstructive and regenerative surgery
- Further Information:
- Note: Giorgio Giatsidis, editor.
- Editors:
- Giatsidis, Giorgio
- Contents:
- Intro; Contents; 1: Principles of Gene Therapy in Reconstructive and Regenerative Surgery; 1.1 Advantages of Gene Therapy Approaches in Reconstructive and Regenerative Surgery; 1.2 Standard Methods for Gene Delivery to Tissues; 1.2.1 Viral Transfection Techniques; 1.2.2 Non-Viral Transfection Techniques; 1.3 Combination of Tissue Engineering Approaches and Gene Transfer Techniques; 1.4 Target Tissues for Gene Therapy Approaches in Reconstructive and Regenerative Surgery; References; 2: Gene Therapy in Skin and Wound Healing; 2.1 Introduction; 2.2 Normal Wound Healing 2.3 Abnormal Wound Healing2.4 Cutaneous Gene Transfer Techniques; 2.4.1 Viral Gene Transfer; 2.4.2 Non-viral Gene Transfer; 2.5 Regulation of Transgene Expression; 2.6 Target Genes for Wound Healing; 2.6.1 Preclinical Studies; 2.6.2 Clinical Studies; 2.7 Challenges and Future Directions; References; 3: Gene Therapy in Pathologic Scars; 3.1 Introduction; 3.2 Basic Gene Therapy Techniques; 3.2.1 Gene Therapies that Alter the Balance Between Cellular Proliferation and Apoptosis; 3.2.2 Gene Therapies that Alter the Balance Between Collagen Synthesis and Degradation 3.2.3 Gene Therapies that Alter the Balance Between Pro-Fibrotic and Anti-Fibrotic Growth Factors/CytokinesReferences; 4: Gene Therapy in Skeletal Muscle Repair and Regeneration; 4.1 Introduction; 4.1.1 Skeletal Muscle: Anatomy and Function; 4.1.1.1 Skeletal Muscle Organization; 4.1.1.2 Skeletal Muscle Healing; 4.1.2 Potential Gene Therapy Targets to AidIntro; Contents; 1: Principles of Gene Therapy in Reconstructive and Regenerative Surgery; 1.1 Advantages of Gene Therapy Approaches in Reconstructive and Regenerative Surgery; 1.2 Standard Methods for Gene Delivery to Tissues; 1.2.1 Viral Transfection Techniques; 1.2.2 Non-Viral Transfection Techniques; 1.3 Combination of Tissue Engineering Approaches and Gene Transfer Techniques; 1.4 Target Tissues for Gene Therapy Approaches in Reconstructive and Regenerative Surgery; References; 2: Gene Therapy in Skin and Wound Healing; 2.1 Introduction; 2.2 Normal Wound Healing 2.3 Abnormal Wound Healing2.4 Cutaneous Gene Transfer Techniques; 2.4.1 Viral Gene Transfer; 2.4.2 Non-viral Gene Transfer; 2.5 Regulation of Transgene Expression; 2.6 Target Genes for Wound Healing; 2.6.1 Preclinical Studies; 2.6.2 Clinical Studies; 2.7 Challenges and Future Directions; References; 3: Gene Therapy in Pathologic Scars; 3.1 Introduction; 3.2 Basic Gene Therapy Techniques; 3.2.1 Gene Therapies that Alter the Balance Between Cellular Proliferation and Apoptosis; 3.2.2 Gene Therapies that Alter the Balance Between Collagen Synthesis and Degradation 3.2.3 Gene Therapies that Alter the Balance Between Pro-Fibrotic and Anti-Fibrotic Growth Factors/CytokinesReferences; 4: Gene Therapy in Skeletal Muscle Repair and Regeneration; 4.1 Introduction; 4.1.1 Skeletal Muscle: Anatomy and Function; 4.1.1.1 Skeletal Muscle Organization; 4.1.1.2 Skeletal Muscle Healing; 4.1.2 Potential Gene Therapy Targets to Aid Skeletal Muscle Regeneration; 4.1.2.1 Current Principle Gene Therapy Targets; 4.1.2.2 Growth Factors; 4.1.2.3 A Signaling Pathway Point of View; 4.1.3 Skeletal Muscle GT in Plastic and Reconstructive Surgery 4.1.4 GT as a Supplement to Tissue Engineering of Skeletal Muscle4.1.4.1 The Satellite Cell Niche; 4.1.4.2 Future Prospects; 4.2 Summary; References; 5: Gene Therapy in Cartilage Repair and Regeneration; 5.1 Introduction; 5.2 Development of AAV Vectors; 5.3 AAV-Based In Vivo Gene Therapy; 5.4 AAV-Based Ex Vivo Gene Therapy; 5.5 AAV-Based Clinical Trials and Challenges; References; 6: Gene Therapy in Tendon Repair and Regeneration; 6.1 Tendon Injuries; 6.2 Phases of Tendon Healing; 6.3 Treatment for Tendon Injuries; 6.4 Gene Therapy for Tendon Injuries 6.5 Gene Therapy to Prevent Adhesion FormationReferences; 7: Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery; 7.1 Introduction; 7.2 Reconstructive Surgery: Current Clinical Practice; 7.3 Gene Therapy; 7.3.1 Viral Vectors; 7.3.2 Non-viral Vectors; 7.4 Principles of Therapeutic Flaps; 7.5 Clinical Application of Therapeutic Flaps; 7.5.1 Head and Neck Cancer; 7.5.2 Breast Cancer; References; 8: Developing a Gene Therapy Clinical Trial: Tips and Tricks; 8.1 US Food and Drug Administration; 8.1.1 Investigational New Drug; 8.1.2 IND Application … (more)
- Publisher Details:
- Cham, Switzerland : Springer
- Publication Date:
- 2018
- Extent:
- 1 online resource
- Subjects:
- 615.8/95
Medicine
Gene therapy
Regenerative medicine
MEDICAL / Pharmacology
Gene therapy
Regenerative medicine
Medicine & Public Health
Plastic Surgery
Regenerative Medicine/Tissue Engineering
Science -- Life Sciences -- Biology -- Molecular Biology
Cellular biology (cytology)
Surgery
Medical -- Surgery -- Plastic & Cosmetic
Plastic & reconstructive surgery
Electronic books - Languages:
- English
- ISBNs:
- 9783319789576
3319789570 - Related ISBNs:
- 9783319789569
3319789562 - Notes:
- Note: Online resource; title from PDF title page (SpringerLink, viewed August 10, 2018).
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.338646
- Ingest File:
- 01_287.xml