Damage-associated molecular patterns in human diseases. Injury-induced innate immune responses / Volume 1, (2018)

• Record Type: Book
• Other Titles: Injury-induced innate immune responses
• Further Information: Note: Walter Gottlieb Land.
• Authors: Land, Walter Gottlieb
• Contents: Intro; Foreword; Reference; Preface; Acknowledgments; Contents; Abbreviations; Part I: The Three Major Paradigms in Modern Immunology; 1: Prologue: The Term "Immunity" over the Course of Time; 1.1 When It All Began; 1.2 Metchnikoff's Cellular Theory of Host Defense; 1.3 Ehrlich's and von Behring's Humoral Theory of Host Defense; 1.4 Outlook; References; 2: The Three Major Paradigms in Immunology; 2.1 Introduction; 2.2 Burnet's Self/Nonself Discrimination: Clonal Selection Theory; 2.3 Janeway's Pattern Recognition Theory; 2.4 The Danger/Injury Theory; 2.4.1 Introductory Remarks 2.4.2 Land's Injury Theory2.4.3 Matzinger's Danger Theory; 2.4.4 The Evolution of the Danger/Injury Model; 2.5 Outlook; References; 3: Epilogue: What Major Paradigm in Immunology Comes Next?; Part II: The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis; 4: Prologue: The Guardians of Homeostasis; 4.1 Introduction; 4.2 Systemic Homeostasis-Tissue Homeostasis-Cellular Homeostasis; 4.3 The Four Major Systems of Homeostasis Surveillance; 4.4 Outlook: The Innate Immune System as an Organ of Perception; References; 5: Innate Immune Recognition Molecules 5.1 Introduction5.2 The "Classical" Cell-Associated Pattern Recognition Receptors; 5.2.1 Introductory Remarks; 5.2.2 Toll-Like Receptors; 5.2.2.1 General Remarks; 5.2.2.2 The Family of Toll-Like Receptors and Their Structure; 5.2.2.3 Toll-Like Receptors at the Plasma Membrane; 5.2.2.4 Toll-Like Receptors at the Endosomal Membranes; 5.2.2.5 Toll-Like Receptor Signalling; 5.2.2.6 Concluding Remarks; 5.2.3 Nucleotide-Binding Oligomerization Domain-Like Receptors; 5.2.3.1 General Remarks; 5.2.3.2 The Family of NOD-Like Receptors and Their Structure 5.2.3.3 Inflammasome-Forming NOD-Like ReceptorsNLRP3 Inflammasome; The NLRP1 Inflammasome; The NLRP6 and NLRP7 Inflammasomes; The NLRP12 Inflammasome; The NLRC4 Inflammasome; 5.2.3.4 Non-inflammasome-Forming NOD-Like Receptors; NOD1/NOD2; NLRP10; NLRX1 and NLRC5; MHC Class II Transactivator; 5.2.3.5 Concluding Remarks; 5.2.4 Helicase Retinoic Acid-Inducible Gene I-Like Receptors; 5.2.4.1 General Remarks; 5.2.4.2 The Family of RIG-I-Like Receptors and Their Structure; 5.2.4.3 RIG-I-Like Receptor Signalling; 5.2.4.4 Concluding Remarks; 5.2.5 Absent in Melanoma 2-Like Receptors 5.2.5.1 General Remarks5.2.5.2 The Family of AIM2-Like Receptors, Their Structure, and Inflammasome Formation; 5.2.5.3 Concluding Remarks; 5.2.6 Other Cytosolic DNA-Sensing Receptors; 5.2.6.1 General Remarks; 5.2.6.2 Cyclic GMP-AMP Synthase: An Important DNA Receptor; 5.2.6.3 Further DNA-Sensing Receptors; 5.2.6.4 DNA-Sensing Receptors Initiating the DNA Damage Response; 5.2.6.5 Concluding Remarks; 5.2.7 C-Type Lectin Receptors; 5.2.7.1 General Remarks; 5.2.7.2 Dectin-1 and Dectin-2; 5.2.7.3 LOX-1, MGL, Mincle, DNGR-1, and MICL; 5.2.7.4 The DC-SIGN Receptor
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (xlviii, 870 pages), illustrations (some color)
• Subjects: 616.07/9; Medicine; Immunology; Internal medicine; Allergy; Medical -- Immunology; Science -- Life Sciences -- Biology -- Molecular Biology; Allergies; Immunology; Medical research; Medical -- Internal Medicine; Clinical & internal medicine; Electronic books
• Languages: English
• ISBNs: 9783319786551; 3319786555
• Related ISBNs: 9783319786544
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed October 22, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.