Molecular basis of resilience adapting to a changing environment /: adapting to a changing environment. (2018)

• Record Type: Book
• Further Information: Note: Patrick L. Iversen.
• Authors: Iversen, Patrick L
• Contents: Intro; Preface; Contents; List of Figures; List of Tables; List of Abbreviations; Chapter 1: Prologue; Background; RNA Based Therapeutics; A New Paradigm; Induced Exon Skipping; Viruses with RNA Genomes; Dark Matter of the Genome; Overview; References; Chapter 2: Social Entropy; Introduction; Challenging Lifestyles; Radiation Exposures; Inevitable Overpopulation; Nonessential Competition; Extending Lifespan; Environmental Adversary; Conclusion; References; Chapter 3: The Threat from Viruses; Introduction; Emerging Infectious Disease (EID) Becomes Endemic Contemporary Emerging Infectious DiseaseTumor Viruses; Cardiovascular Viruses; Finding an Emerging Infectious Disease; Non-Pathogenic Viral Infections; Antiviral Drugs; Antibodies; Vaccines; Viruses Not Targeted by Antiviral Drugs, Monoclonal Antibodies nor Vaccines; An Unfavorable Climate for Antiviral Therapeutics; Environmental Viral Reservoirs; Conclusion; References; Chapter 4: Nonlinear Anomalies; Studies in Cell Culture; Cultured Cells Are Temperamental; Stem Cells; Microphysiological Systems; Animal Models; The Animal Rule; Opposing Philosophies; Conclusion; References Chapter 5: Bacterial Infectious Disease ThreatIntroduction; Pathogenic Bacteria; Bacterial Outbreaks; Oncogenic Bacteria; Syphilis; Tuberculosis; Horizontal Gene Transfer; A Strange Case of Horizontal Gene Transfer; The Environment and Antibiotics; Microbiome Considerations; Summary; References; Chapter 6: CURE 2000; Introduction; A Brief Look at History; Leukemia; Guardian of the Genome; OL(1)p53; Beyond p53; The Modern Era; References; Chapter 7: Chemicals in the Environment; Introduction; The Pharmaceutical Industry; Drugs in the Environment; Antibacterials; Antivirals; Analgesics HormonesAntidepressants; Beta-Blockers; Hormone-Mimetics; Endocrine Disrupting Chemicals (EDC); Chemicals in Food; Air Pollution; Volatile Organic Compounds (VOC); Pesticides in the Environment; Chemical Carcinogenesis; Emerging Role of Ribonucleic Acid Damage; Conclusion; References; Chapter 8: Immune Defense; Introduction; Prokaryotic Defenses: A Primitive Immune System; Innate Immune System; Pattern Recognition Receptors (PRRs); Adaptive Immune System; Autoimmunity; Immunosuppression; Immune White Space; Conclusion; References; Chapter 9: Active Oxygen Defenses; Introduction Cytochrome P450CYP Activities; CYPs are Redundant and Essential; Transcriptome Plasticity and Genome Evolution; Infection Suppression of Drug Metabolism; Host-Pathogen CYP Countermeasures; Carbon Monoxide Refines and Focuses Host Defenses; Defense Responses to Pregnancy; Nuclear Hormone Receptors Bridge Immune and Metabolic Defenses; Metabolic Defenses; CYP Role in Cell Proliferation; Conclusions; References; Chapter 10: Analog Genetics; Introduction; One Gene-One Enzyme; Central Dogma; Transcriptome Plasticity; Duchenne Muscular Dystrophy; Alternate Translation Start Sites
• Publisher Details: Cham, Switzerland : Springer Nature
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 579.25; Medicine; RNA viruses; Resilience (Ecology); Environmental health; SCIENCE / Life Sciences / Biology; SCIENCE / Life Sciences / Microbiology; Science -- Life Sciences -- Biology -- Molecular Biology; Medical research; Toxicology; Medical -- Pharmacology; Pharmacology; Electronic books
• Languages: English
• ISBNs: 9783319981642; 3319981641
• Related ISBNs: 3319981633; 9783319981635
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.