Organ regeneration based on developmental biology. (2017)

• Record Type: Book
• Further Information: Note: Edited by Takashi Tsuji, editor.
• Editors: Tsuji, Takashi
• Contents: Dedication; Preface; Contents; List of Contributors; Chapter 1: Telencephalic Tissue Formation in€3D Stem Cell Culture; 1.1 Introduction; 1.2 The Cerebral Cortex; 1.2.1 Development of€the€Cerebral Cortex In€Vivo; 1.2.2 3D Cortical Tissue Generation In€Vitro; 1.3 Ventralizing Telencephalic Tissues; 1.3.1 Development of€the€Ventral Telencephalon In€Vivo; 1.3.2 Development of€the€Ventral Telencephalon In€Vitro; 1.4 Dorsalizing Telencephalic Tissues; 1.4.1 Development of€Dorsomedial Telencephalic Structure In€Vivo; 1.4.2 Generation of€Dorsomedial Telencephalic Tissues In€Vitro. 1.5 Closing Remarks and€Future PerspectiveReferences; Chapter 2: Self-Organized Cerebellar Tissue from€Human Pluripotent Stem Cells and€Its Application to€Clinical Medicine; 2.1 Introduction; 2.2 Self-Organization of€Cerebellar Tissue from€hPSCs in€3D Culture; 2.2.1 Development of€Mammalian Cerebellum; 2.2.2 Attempt to€Generate Cerebellar Neurons from€PSCs; 2.2.3 Self-Induction of€Cerebellar Neurons from€hPSCs; 2.2.4 Self-Formation of€Polarized Cerebellar Structure; 2.3 Construction of€Human Cerebellar Disease Models with€Patient-Derived iPSCs; 2.4 Conclusion; References. Chapter 3: Functional Pituitary Tissue Formation Recapitulating Hypothalamus and€Pituitary Development Using ES/iPS Cells3.1 Introduction; 3.2 A Need for€Hypothalamus and€Adenohypophysis Regenerative Medicine; 3.3 Mouse Embryonic Stem Cells; 3.4 Pituitary Gland Embryology; 3.5 Three-Dimensional ES Cell Culture; 3.6 Induction of€Hypothalamic Neurons from€Mouse ES Cells; 3.7 Two-Layer Formation In€Vitro Is the€First Step of€Adenohypophysis Differentiation; 3.8 Self-Formation of€Rathke's Pouch; 3.9 Differentiation into Hormone-Producing Endocrine Cells; 3.10 Functionality of€Induced ACTH+ Cells. 3.11 Effect of€Transplantation into€Hypophysectomized Model Animals3.12 Adaptation to€Human ES/iPS Cell Culture; 3.13 Future Perspectives; References; Chapter 4: Inner Ear Organoids: Recapitulating Inner Ear Development in€3D Culture; 4.1 Introduction; 4.2 Inner Ear Development; 4.2.1 Formation of€the€Preplacodal Region; 4.2.2 Formation of€the€Otic Epibranchial Placode Domain; 4.2.3 Formation of€the€Otic Placode; 4.3 Generation of€Inner Ear Organoids; 4.3.1 Formation of€Nonneural Ectoderm (NNE); 4.3.2 Formation of€the€Preplacodal Region (PPR); 4.3.3 Formation of€the€Otic Placode. 4.3.4 Self-Guided Differentiation to€the€Inner Ear Sensory Epithelium4.3.5 Morphologic and€Functional Analysis of€Inner Ear Sensory Epithelia; 4.4 Potential Applications and€Limitations; References; Chapter 5: Functional Tooth Regeneration; 5.1 Introduction; 5.2 Tooth Organogenesis; 5.3 Tissue Repair and€Engineering by€Using Dental Tissue-ƯDerived Stem Cells and€Cytokines; 5.3.1 Stem-Cell Therapy; 5.3.1.1 Dentin-Pulp Tissue Repair; 5.3.1.2 Periodontal Tissue Repair; 5.3.2 Cytokine Approach; 5.3.3 Bioengineered Root Regeneration by€Tissue Engineering Technology.
• Publisher Details: Singapore : Springer
• Publication Date: 2017
• Extent: 1 online resource (xiii, 257 pages), illustrations (some color)
• Subjects: 610.28; Life sciences; Regenerative medicine; Organs (Anatomy); TECHNOLOGY & ENGINEERING -- Biomedical; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Organs (Anatomy); Regenerative medicine; Regenerative Medicine; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Life Sciences -- Biology -- Developmental Biology; Cellular biology (cytology); Developmental biology; Stem cells; Developmental biology; Science -- Life Sciences -- Cytology; Genetics (non-medical); Electronic books
• Languages: English
• ISBNs: 9789811037689
• Related ISBNs: 981103768X; 9789811037665; 9811037663
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed April 7, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.