Cardiac extracellular matrix : fundamental science to clinical applications /: fundamental science to clinical applications. (2018)

• Record Type: Book
• Further Information: Note: Edited by Eric G. Schmuck, Peiman Hematti, Amish N. Raval.
• Editors: Schmuck, Eric G; Hematti, Peiman; Raval, Amish N
• Contents: Intro; Dedication; Introduction; Contents; About the Editors; Chapter 1: Biomechanical Properties and Mechanobiology of Cardiac ECM; 1.1 Introduction; 1.1.1 Overall Structure and Function of the Heart; 1.1.2 Different Cardiac Cell Types; 1.1.3 The ECM Composition in Cardiac Tissues; 1.2 Mechanical Measurement of Cardiac Tissues; 1.2.1 Ex Vivo Measurement; 1.2.2 In Vivo Measurement; 1.3 Biomechanical Properties of Cardiac Tissues; 1.3.1 Myocardium; 1.3.2 The Right Ventricle Is Different from the Left Ventricle; 1.3.3 Heart Valves; 1.4 Biomechanical Responses and Mechanobiology of Myocardium 1.4.1 Types of Mechanical Factors1.4.2 Mechanical Response of Cardiac Tissue; 1.4.3 Mechanical Response of Cardiac Cells; 1.4.4 Importance of Cardiac ECM; 1.5 Summary; References; Chapter 2: Imaging the Cardiac Extracellular Matrix; 2.1 Introduction; 2.2 Collagen, Fibrosis, and Other Biological Targets for ECM Imaging; 2.3 ECM Imaging Methods; 2.4 Organ-Scale Imaging; 2.4.1 Magnetic Resonance Imaging; 2.4.2 Ultrasound; 2.4.3 Nuclear Imaging; 2.5 Cellular-Scale Imaging; 2.5.1 Tissue Staining Protocols; 2.5.2 Nonlinear Optical Microscopy; 2.5.3 Electron Microscopy; 2.6 Future Directions 2.7 ConclusionReferences; Chapter 3: Animal Models and Cardiac Extracellular Matrix Research; 3.1 Animal Models of Heart Disease; 3.1.1 Introduction; 3.2 Transgenic Models of ECM; 3.3 Small Animal Models of Cardiovascular Disease (Fig. 3.1); 3.4 Large Animal Models of Cardiovascular Disease (Fig. 3.2); 3.5 Summary; References; Chapter 4: Applications of Cardiac Extracellular Matrix in Tissue Engineering and Regenerative Medicine; 4.1 Introduction; 4.2 Cardiac Extracellular Matrix; 4.2.1 Composition and Role of the Cardiac Extracellular Matrix; 4.2.2 The Role of ECM in Cardiac Development 4.2.3 Alterations to ECM Composition and Structure from Injury and Disease4.3 Modulation of cECM in Regenerative Medicine Approaches in the Heart; 4.3.1 The Role of cECM Proteins in Remodeling Post-Injury: Potential Strategies to Direct Cardiac Tissue Repair or Regeneration; 4.3.2 Modulation of Protease Activity During Remodeling as a Tool for Cardiac Repair; 4.4 Bottom-Up Versus Top-Down Approaches in ECM-Based Cardiac Tissue Engineering; 4.4.1 Bottom-Up; 4.4.1.1 Isolation of ECM; 4.4.1.2 2D Platforms for Assessment of cECM on Cardiac Cells and Tissues 4.4.1.3 Use of Biomaterial Scaffolds: 3D Platforms for Cardiac Tissue Engineering4.4.1.4 3D Printing; 4.4.2 Top-Down; 4.4.2.1 Directed Self-Assembly of Cardiac Tissue; 4.4.2.2 Decellularization of the Whole Heart; 4.4.2.3 Recellularization Techniques, Promise, and Pitfalls; 4.5 Open Questions for Engineering the Cardiac Extracellular Matrix; 4.6 Conclusion; References; Chapter 5: Whole Cardiac Tissue Bioscaffolds; 5.1 Introduction; 5.2 Decellularization; 5.2.1 Chemical Decellularization; 5.2.2 Enzymatic Decellularization; 5.2.3 Physical Decellularization; 5.3 Recellularization
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (xii, 246 pages), illustrations (some color)
• Subjects: 612.1/7046; Life sciences; Heart -- Cytology; Extracellular matrix; Medical -- Cardiology; Medical -- Allied Health Services -- Medical Technology; Medical -- Surgery -- Thoracic; Cardiovascular medicine; Biomedical engineering; Cardiothoracic surgery; Cytology; Cardiology; Biomedical engineering; Heart_xSurgery; Science -- Life Sciences -- Biology -- Molecular Biology; Cellular biology (cytology); Electronic books
• Languages: English
• ISBNs: 9783319974217; 3319974211
• Related ISBNs: 9783319974200
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed September 28, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.