The therapeutic use of N-Acetylcysteine (NAC) in medicine. (2018)

• Record Type: Book
• Further Information: Note: Richard Eugene Frye, Michael Berk, editors.
• Editors: Frye, Richard Eugene; Berk, Michael
• Contents: Intro; Preface; Contents; About the Editors; Part I: Introduction; 1: History of N-Acetylcysteine; 1.1 N-Acetylcysteine, the Antidote to Acetaminophen Overdose; 1.2 Unintentional Acetaminophen Overdose; 1.3 Over-the-Counter NAC; 1.4 NAC-Acetaminophen: Formulate the Antidote Along with the Drug?; 1.5 How Did We, Two Basic Scientists, Get Involved with Considering the Clinical Uses of NAC?; 1.6 Growing Cells at Physiological Oxygen Levels; 1.7 NAC and HIV; 1.8 NAC Treatment in Disease; 1.9 Contrast Nephropathy; 1.10 Cystic Fibrosis; 1.11 Autism; 1.12 Summary; References Part II: The Basic Science of N-acetylcysteine (NAC)2: Neurotransmitter Systems: Glutamate; 2.1 Overview of Glutamatergic Neurotransmission; 2.2 Regulation of Extracellular Glutamate Levels by Autoreceptors and Glutamate Uptake; 2.3 Regulation of Glutamate Homeostasis by Cystine-Glutamate Exchangers (System xc-) and NAC; 2.4 Regulation of Glial Glutamate Transporters by NAC; 2.5 Possible Regulation of Glutamate Homeostasis by NAC Analogues; 2.6 Summary; References; 3: Neurotransmitter Systems: Dopamine; 3.1 Introduction; 3.2 Methodology; 3.3 Summary of Systematic Literature Review 3.3.1 Alzheimer's Disease3.3.2 Environmental Toxin; 3.3.2.1 Polychlorinated Biphenyls (PCBs); 3.3.2.2 Tungsten; 3.3.3 Ischemic Brain Injury; 3.3.4 Parkinson's Disease; 3.3.4.1 Animal Studies; 3.3.4.2 Cellular Studies; Dopamine (Toxin); Dopamine-Related Compounds (Toxin); 3.3.5 Pituitary Tumor; 3.3.6 Renal Pathology; 3.3.7 Schizophrenia; 3.3.8 Substance Use Disorders; 3.3.8.1 Amphetamine; Animal Studies; Cellular Studies; 3.3.8.2 Cocaine; 3.3.8.3 Methamphetamine; 3.3.9 Vitiligo; 3.4 Summary; References; 4: Oxidative Stress in Psychiatric Disorders; 4.1 Introduction 4.2 Oxidative Stress and the Anti-oxidation System4.2.1 Oxidative Stress; 4.2.2 Antioxidant Systems in the Body; 4.2.3 Biomarkers of Oxidative Stress; 4.2.4 Oxidative Stress in the Developing Brain; 4.3 Oxidative Stress and Psychiatric Disorders; 4.3.1 Oxidative Stress and Autism Spectrum Disorder; 4.3.1.1 Peripheral Biomarkers of Redox Balance in ASD; 4.3.1.2 Evaluation of Brain GSH Levels in Individuals with ASD by 1H MRS; 4.3.1.3 Assessing Redox Balance from Postmortem Brain Samples of Individuals with ASD; 4.3.1.4 Oxidative Stress and Mitochondrial Dysfunction in ASD 4.3.2 Oxidative Stress and Schizophrenia4.3.2.1 Peripheral Biomarkers of Redox Balance in Schizophrenia; 4.3.2.2 Evaluation of Brain GSH Levels in Individuals with Schizophrenia by 1H MRS; 4.3.2.3 Assessing Redox Balance from Postmortem Brain Samples of Individuals with Schizophrenia; 4.3.2.4 Oxidative Stress and Other Pathophysiologic Mechanisms of Schizophrenia; 4.3.3 Oxidative Stress and Bipolar Disorder; 4.3.3.1 Peripheral Biomarkers of Redox Balance in Bipolar Disorder; 4.3.3.2 Brain GSH Levels in Individuals with Bipolar Disorder by 1H MRS
• Publisher Details: Singapore : Adis
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 615.1; Medicine; Drugs -- Research; Drugs -- Testing; MEDICAL / Pharmacology; Medical -- Pharmacology; Pharmacology; Toxicology; Electronic books
• Languages: English
• ISBNs: 9789811053115; 9811053111
• Related ISBNs: 9789811053108
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed September 25, 2018)
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.