Testosterone : from basic to clinical aspects /: from basic to clinical aspects. (2017)

• Record Type: Book
• Further Information: Note: Alexandre Hohl, editor.
• Editors: Hohl, Alexandre
• Contents: Preface; Contents; Contributors; 1: The History of Testosterone and The Testes: From Antiquity to Modern Times; "The Oldest Key to the Endocrine Treasure Trove: The Testicles"; Effects of Testis Removal; Lessons from Experimental Testis Transplantation; Erroneous Conclusions from Berthold's Experiments; Testes for Organotherapy; Isolation and Synthesis of Testosterone; Evolution of Testosterone Preparations for Clinical Use; References; 2: Androgen Receptor in Health and Disease; Androgenic Hormones; Biosynthesis of Testosterone and 5[alpha]-Dihydrotestosterone ; Serum Testosterone. Enzymatic Defects in Testosterone Synthesis17[beta]-Hydroxysteroid Dehydrogenase Type III Deficiency; 46, XY DSD with Normal or High Testosterone Secretion; Defects in the Conversion of Testosterone in Dihydrotestosterone: 5 Alpha Reductase 2 Deficiency; Defects in Testosterone Action: Androgen Receptor Defects; Management of Patients with 46, XY DSD; Hormonal Therapy in Patients With DSD with Male Social Sex; Surgical Procedures in Patients With DSD with Male Social Sex; References; 4: Utility and Limitations in Measuring Testosterone; Introduction. T and DHT Interact with AR in the Target Cell Two Ligands and One Receptor; Importance of Estrogens in the Male; The Androgen Receptor (AR); Background; Functional Domains of AR; DNA-Binding Domain (DBD) (Residues 555-623); Ligand Binding Domain (LBD, Residues 666-919); Hinge Region (Residues 624-665); AR Nuclear Export; Amino-Terminal Domain (NTD) (Residues 1-556); Receptor Dimerization; Coregulatory Proteins; AR in Clinical Medicine; AR PolyQ Repeat; Androgen Insensitivity Syndromes (AIS); AR and the Prostate; Prostate Embryogenesis. Early AR-Dependent Events in Prostate Carcinogenesis Role of AR in Castration Resistant Prostate Cancer; AR and Breast Cancer; AR and Bone Health; Development of ARKO Mice; Specific Conditional Knock-Out of AR in the Testes; Sertoli Cell Specific ARKO Models; Leydig Cell-Specific ARKO Male Mice; Peritubular Myoid (PTM) Cell-Specific ARKO Mice; Germ Cell-Specific ARKO Male Mice; Function of AR in the Prostate and Accessory Glands; AR Functions in Prostatic Stroma; AR Functions in Prostatic Epithelium; AR Functions in Seminal Vesicles (SV); AR Functions in the Epididymis. Function of AR in Testicular Descent Functions of AR in Females; AR and Breast Development; AR and Uterus; AR and PCOS; References; 3: Physiology of Male Gonadotropic Axis and Disorders of Sex Development; Introduction; Control of Male Gonadotropic Axis Function; GnRH Secretion; LH Secretion; FSH Secretion; 46, XY Disorders of Sex Development; 46, XY DSD due to Low Testosterone Secretion; Defects in Formation of the Testes; 46, XY Gonadal Dysgenesis; Defects of Testosterone Production; LH/hCG Insensibility: Leydig Cell Hypoplasia; 46, XY DSD Due to Cholesterol Synthesis Defects.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource (xiii, 414 pages), illustrations (some color)
• Subjects: 612.6/1; Medicine; Testosterone; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Testosterone; Testosterone; Medical -- Urology; Medical -- Sports Medicine; Health & Fitness -- Diseases -- Genetic; Urology & urogenital medicine; Sports injuries & medicine; Reproductive medicine; Endocrinology; Urology; Sports medicine; Reproductive Medicine; Medical -- Endocrinology & Metabolism; Endocrinology; Electronic books
• Languages: English
• ISBNs: 9783319460864; 3319460862; 3319460846; 9783319460840
• Related ISBNs: 9783319460840
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed April 12, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.