1. Introduction: The diverse aromatic δ lactones 2. Natural products: A major source of isocoumarins 3. Bioactive isocoumarins: their role in pharmaceutical research 4. Synthesis of isocoumarins: traditional and transition metal catalyzed methods 5. Preparation of Thienopyranones 6. Synthesis of seleno and telluro isocoumarins 7. Synthesis of a-pyranone fused with nitrogen containing heterocycles 8. Synthesis of phosphaisocoumarins 9. Synthesis of nature’s isocoumarins 10. Synthesis of isocoumarins of pharmacological interest 11. Isocoumarins in organic synthesis: Synthetic applications 12. Conclusions
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