Core concepts in acute kidney injury. ([2018])

• Record Type: Book
• Further Information: Note: Sushrut S. Waikar, Patrick T. Murray, Ajay K. Singh, editors.
• Editors: Waikar, Sushrut S; Murray, Patrick T; Singh, Ajay, 1960-
• Contents: Intro; Preface; Contents; Contributors; Part I: Epidemiology and Diagnosis; 1: Epidemiology, Incidence, Risk Factors, and Outcomes of Acute Kidney Injury; 1.1 Background; 1.2 Epidemiology; 1.3 Risk Factors for the Development of AKI; 1.4 CKD, CVD and ESRD as Possible Outcomes After an Episode of AKI; 1.5 Risk Factors for Poor Outcomes Following AKI; 1.6 Potential Pathogenetic Mechanisms for AKI: CKD Transition; References; 2: Definition and Classification of Acute Kidney Injury; 2.1 Diagnosis and Staging of AKI; 2.2 RIFLE Criteria 2.3 Acute Kidney Injury Network (AKIN) Definition and Staging Criteria2.4 Kidney Disease: Improving Global Outcomes (KDIGO) Classification; 2.5 AKI Definition and Staging in Pediatric Patients; 2.6 Validation of AKI Definitions; 2.7 Limitations of the Current Definitions and Staging Criteria; 2.8 Use of AKI Definitions in Epidemiology and Clinical Research; 2.9 Utility of AKI Definitions and Staging in Clinical Care; References; 3: Diagnostic Approach: Differential Diagnosis, Physical Exam, Lab Tests, Imaging, and Novel Biomarkers; 3.1 Differential Diagnosis 3.1.1 Rethinking the Differential Diagnosis of AKI3.2 Physical Exam; 3.3 Lab Tests; 3.3.1 Blood Tests; 3.3.2 Urinary Test; 3.4 Imaging; 3.5 Novel Biomarkers; References; Part II: Pathophysiology; 4: Overview of Pathophysiology of Acute Kidney Injury: Human Evidence, Mechanisms, Pathological Correlations and Biomarkers and Animal Models; 4.1 Introduction: Evidence of the Human Significance of Acute Kidney Injury; 4.2 Defining Acute Kidney Injury; 4.2.1 Traditional Acute Kidney Injury Descriptors; 4.2.2 Functional Descriptors: Serum Creatinine, SCr, and Oliguria 4.3 Aetiology of Acute Kidney Injury4.4 Pathophysiology of Acute Kidney Injury; 4.4.1 Tubular Injury and Linked Biomarkers; 4.4.2 Apoptosis and Mitochondrial Associations; 4.4.3 Necrosis and Necroptosis; 4.4.4 Autophagic Cell Death; 4.4.5 Relationship Between Tubular Damage and Reduced GFR; 4.4.6 Endothelial and Vascular Injury; 4.4.7 Inflammation and the Immune Response; 4.5 Biomarkers; 4.5.1 Damage Biomarkers for Early Diagnosis of AKI; 4.6 Novel Roles for Damage Biomarkers in Acute Kidney Injury; 4.6.1 Differential Diagnosis; 4.6.2 Biomonitoring Treatment Success or Failure 4.7 Recovery and Renal Reserve4.7.1 Maladaptive Healing and Chronic Kidney Disease; 4.8 Animal Models; References; 5: Tubular Physiology in Acute Kidney Injury: Cell Signalling, Injury and Inflammation; 5.1 Introduction; 5.2 Cell Polarity in AKI; 5.2.1 Acute Injury; 5.3 Cell Signalling in AKI; 5.3.1 Arachidonic Acid Metabolites; 5.3.2 Adenosine Triphosphate (ATP); 5.3.3 Nitric Oxide; 5.3.4 Dopamine; 5.3.5 Angiotensin II; 5.3.6 Bradykinin; 5.4 Heme Oxygenase-1; 5.4.1 Heme Oxygenase and the Kidney; 5.4.2 Renal Blood Flow and the Microcirculation
• Publisher Details: New York, NY, U.S.A : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.61; Medicine; Kidneys -- Wounds and injuries; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Nephrology; Medical -- Nephrology; Renal medicine & nephrology; Electronic books
• Languages: English
• ISBNs: 9781493986286; 1493986287
• Related ISBNs: 9781493986262; 1493986260
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed September 19, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.