Human neural stem cells : from generation to differentiation and application /: from generation to differentiation and application. ([2018])

• Record Type: Book
• Further Information: Note: Leonora Buzanska, editor.
• Editors: Buzanska, Leonora
• Contents: Intro; Contents; Part I: Derivation and/or Generation of Human Neural Stem Cells; Chapter 1: Derivation of Neural Stem Cells from the Developing and Adult Human Brain; 1.1 Foetal Neural Stem Cells (NSCs); 1.1.1 Mitogens Used for In Vitro Proliferation of hNSCs; 1.1.2 Longer-Term Growth of hNSCs; 1.1.3 Regional Differences; 1.2 Adult Neural Stem Cells; 1.3 Good Manufacturing Practice Production; 1.4 Conclusion; References; Chapter 2: Human Somatic Stem Cell Neural Differentiation Potential; 2.1 Afterbirth Somatic Tissues; 2.1.1 Placenta; 2.1.1.1 Maternal Decidua-Derived Cells 2.1.1.2 Fetal Chorion-Derived Cells2.1.2 Amnion and Amniotic Fluid; 2.1.2.1 Amniotic Epithelial-Derived Cells; 2.1.2.2 Amnion Mesenchyme-Derived Cells; 2.1.2.3 Amniotic Fluid-Derived Cells; 2.1.3 The Umbilical Cord; 2.1.3.1 Human Umbilical Cord Blood (hUCB); 2.1.3.2 Human Umbilical Cord Tissue (Wharton Jelly); 2.2 Adult Somatic Tissues; 2.2.1 Blood; 2.2.1.1 Menstrual Blood; 2.2.1.2 Peripheral Blood; 2.2.2 Bone Marrow; 2.3 Direct Comparison of the Neural Differentiation Capabilities of the Perinatal and Adult Somatic Tissues; 2.4 Conclusions; References Chapter 3: Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury3.1 Introduction; 3.1.1 iPS-NPs Derivation and Differentiation; 3.1.2 iPS-NPs in the Treatment of Injured CNS; 3.1.3 iPS-NPs in the Treatment of SCI; 3.1.4 iPS-NPs in the Treatment of Acute SCI; 3.1.5 iPS-NPs in the Treatment of Chronic SCI; 3.1.6 iPS-NPs in the Treatment of Stroke; 3.1.7 iPS-NPs and Their Translation to Clinical Medicine; 3.2 Conclusions; References; Chapter 4: Generation of Human Neural Stem Cells by Direct Phenotypic Conversion; 4.1 Introduction 4.1.1 Neural Stem Cells4.1.2 Reprogramming Technology; 4.1.3 Purpose; 4.2 Generation of iNSC; 4.2.1 Generation of Genome-Integrated iNSC; 4.2.2 Generation of Genome Integration-Free iNSC; 4.2.3 Rationale of Direct Phenotypic Conversion; 4.3 Application Fields of iNSC; 4.3.1 Application Fields of Genome-Integrating iNSC; 4.3.2 Application Fields of Genome Integration-Free iNSC; 4.4 Pros and Cons of iNSC; 4.5 Conclusions and Future Perspectives; References; Part II: Differentiation and Underlying Mechanisms; Chapter 5: Epigenetic Regulation of Human Neural Stem Cell Differentiation 5.1 Introduction5.2 Molecular Mechanisms of Epigenetics; 5.3 Epigenetic Mechanism Regulating Generation of NSCs from Pluripotent Stem Cells and Neuronal Differentiation of NSCs; 5.4 Epigenetic Mechanisms Regulating Astrocytic Differentiation of NSCs; 5.5 Epigenetic Mechanisms Regulating Oligodendrocytic Differentiation of NSCs; 5.6 Investigation of Neurological Disorders Using Patient-Derived iPSCs; 5.7 Concluding Remarks and Perspective; References; Chapter 6: Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophrenia
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 612.8; Life sciences; Neural stem cells; MEDICAL / Physiology; SCIENCE / Life Sciences / Human Anatomy & Physiology; Medical -- Genetics; Medical -- Neuroscience; Medical genetics; Neurosciences; Stem cells; Medical genetics; Neurosciences; Gene therapy; Human genetics; Science -- Life Sciences -- Cytology; Genetics (non-medical); Electronic books
• Languages: English
• ISBNs: 9783319934853; 3319934856
• Related ISBNs: 9783319934846
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed September 18, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.