Biology in stem cell niche. (2015)

• Record Type: Book
• Further Information: Note: Kursad Turksen, editor.
• Authors: Turksen, Kursad
• Contents: Preface; Contents; Editor and Contributors; 1 The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence; 1 Introduction; 2 Cell-Cell Interactions; 2.1 Endothelial Cells; 2.2 Mesenchymal-Derived Cells of the Hematopoietic Stem Cell Niche; 2.2.1 Chemokine Ligand 12 Expressing Cells; 2.2.2 Nestin Expressing Cells; 2.2.3 Osteoblasts; 2.2.4 Leptin-Receptor Expressing Cells; 2.2.5 CD146 Expressing Cells; 2.2.6 Bone Cartilage Stromal Progenitor Cells; 3 Other Niche Cells; 3.1 Megakaryocytes; 3.1.1 Non-myelinated Schwann Cells; 3.1.2 Monocytes/Macrophages 3.1.3 Sympathetic Nervous System4 Hematopoietic Stem Cell Niche Structure and Physiology; 4.1 Integrins; 4.2 Wnts; 4.3 Hypoxia; 4.4 Energetics; 5 Intrinsic Regulators of Cell Cycle; 6 Conclusions; Acknowledgments; References; 2 The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix; 1 Introduction; 2 Defining the Limbus as the Residence Site for Corneal Stem Cells; 3 The Limbus: Its Structure and Composition; 3.1 Corneal Epithelial Stem Cells and Their Niche: Cells that Interact with the Limbal Stem Cell Reservoir 3.1.1 Epithelial Cells3.1.2 Melanocytes; 3.1.3 Langerhans' Cells; 3.1.4 Stromal Cells; 3.1.5 Corneal Innervation; 3.2 Corneal Epithelial Stem Cells and Their Niche: Basal Membrane and Extracellular Matrix Components; 3.3 Corneal Epithelial Stem Cells and Their Niche: Growth Factors and Cytokines; 4 The Niche as Regulator of Limbal Stem Cells; 5 Corneal Epithelial Stem Cells: Renewal and Wound Healing; 6 Limbal Stem Cells and Therapy; 7 Conclusion; Acknowledgements; References; 3 Emerging Engineering Strategies for Studying the Stem Cell Niche; 1 Introduction; 2 Stem Cells and Their Niches 3 Stem Cell-ECM Interactions3.1 Stem Cell Adhesion to Niche ECM via Integrins; 3.2 Cadherins, Another Class of Adhesion Receptors; 3.3 Molecular Sequestering of Growth Factors and Cytokines by ECM; 4 Seminal Engineering Strategies -- Establishing a Foundation; 4.1 Micro/Nanofabrication Techniques for Generating Pre-Printed Topographies; 4.2 Micropatterning Techniques to Relate Stem Cell Shape to Behavior; 4.3 Soft Matter Hydrogel Systems with Predefined Characteristics; 5 Second Generation Engineering Strategies -- Increased Complexity with a Focus on Spatiotemporal Control 5.1 Biomaterials with Tunable Properties5.2 Spatiotemporal Control over Topography; 5.3 Spatiotemporal Control over Matrix Stiffness; 5.4 Dynamic Control of Integrin-Based Focal Adhesions; 6 Dissecting Cell-Cell Interactions within the Stem Cell Niche; 7 Early Approaches for Studying Stem Cell-Niche Cell Interactions In Vitro; 7.1 Patterned Bulk Stem Cell Co-Cultures; 7.2 Patterned 3D Stem Cell Co-Cultures; 8 Shifting Focus to Single-Cell Resolution and Artificial Niches; 8.1 Microfluidic Approaches for Single-Cell Co-Cultures; 8.2 Artificial Stem Cell-Niche Cell Signaling Approaches
• Publisher Details: Cham : Humana Press
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 616.02/774; Life sciences; Stem cells; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Stem cells; Technology & Engineering -- Engineering (General); Biomedical engineering; Biomedical engineering; Science -- Life Sciences -- Cytology; Genetics (non-medical); Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319217024
• Related ISBNs: 331921702X; 9783319217017
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed October 20, 2015)
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.