DNA replication : from old principles to new discoveries /: from old principles to new discoveries. ([2017])

• Record Type: Book
• Further Information: Note: Hisao Masai, Marco Foiani, editors.
• Editors: Masai, Hisao; Foiani, Marco
• Contents: Historical perspective of eukaryotic DNA replication -- Regulation of replication origins -- Molecular mechanism for chromatin regulation during MCM loading in mammalian cells -- Initiation of DNA replication at the chromosomal origin of E. coli, oriC -- Initiation of DNA replication in the archaea -- Mechanism of lagging strand DNA replication in eukaryotes -- Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication -- Termination of eukaryotic replication forks -- Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex -- Architecture of The Saccharomyces cerevisiae Replisome -- Replication domains: genome compartmentalization into functional replication units -- Rif1-dependent regulation of genome replication in mammals -- G-quadruplexes and DNA replication origins -- Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions -- Chromatin replication and histone dynamics -- The temporal regulation of S phase proteins during G1 -- Roles of SUMO in replication initiation, progression, and termination -- The multiple roles of ubiquitylation in regulating challenged DNA replication -- Regulation of mammalian DNA replication via the ubiquitin-proteasome system -- Coordinating replication with transcription -- Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites -- Cyclin E deregulation and genomic instability -- Replication through repetitive DNA elements and their role in human diseases.
• Publisher Details: Singapore : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource (xii, 581 pages), illustrations (some color)
• Subjects: 572.8/645; Life sciences; DNA replication; Cytogenetics; Cytology; SCIENCE / Life Sciences / Biochemistry; Cytogenetics; Cytology; DNA replication; DNA Replication; Medical -- Genetics; Science -- Life Sciences -- Biochemistry; Medical genetics; Biochemistry; Human genetics; Biochemistry; Science -- Life Sciences -- Biology -- Molecular Biology; Cellular biology (cytology); Electronic books
• Languages: English
• ISBNs: 9789811069550; 9811069557
• Related ISBNs: 9789811069543; 9811069549
• Notes: Note: Includes bibliographical references.; Note: Description based on online resource; title from electronic title page (SpringerLink, viewed April 24, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.