Standards for ocular toxicology and inflammation. (2018)

• Record Type: Book
• Further Information: Note: Brian C. Gilger, Cynthia S. Cook, Michael H. Brown, editors.
• Editors: Gilger, Brian C; Cook, Cynthia S; Brown, Michael H
• Contents: Intro; Preface; Contents; Chapter 1: Standards for Conducting Ophthalmic Examinations in Laboratory Animals; Introduction; Routine Examination; Slit-Lamp Biomicroscopy; Indirect/Direct Ophthalmoscopy; Pretest Examination; Additional Ophthalmic Diagnostic Procedures; Tonometry; Pachymetry; Fluorescein Staining; Photographic Documentation; Fluorescein Angiography; Electroretinography/Visual Evoked Potential; Optical Coherence Tomography; Specular Microscopy; Conclusion; References; Chapter 2: Standard Operating Procedures for Common Laboratory Animal Ocular Procedures; Introduction Aqueocentesis/Intracameral InjectionIntravitreal Injection/Vitreocentesis; Mouse; Rat; Rabbit; Porcine/Canine; Nonhuman Primates; Subconjunctival Injection; Retrobulbar; Subretinal Injections; Rodents; Large Animals; Rabbit; Porcine/Canine; Nonhuman Primate; Globe/Tissue Dissection for Ocular Drug Analysis and Pharmacokinetics; Conclusions; References; Chapter 3: Harmonization of Lesion Nomenclature in Laboratory Animals; Introduction; Orbit and Globe; Eyelids, Adnexa, and Conjunctiva; Cornea and Sclera; Aqueous/Anterior Chamber; Iris and Ciliary Body; Lens; Vitreous Humor Retina, Choroid, and Optic NerveNeuro-Ophthalmology; Conclusions; References; For Additional Information of the SEND and INHAND Initiatives, Please See These Additional Resources:; Chapter 4: Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals; Introduction; Rodents; CD-1 Mice; Sprague-Dawley Rat; CD Rats; Wistar Rats; Long-Evans Rats; Other Rodent Species; Guinea Pig; Hamster; Rabbits; Beagles; Laboratory Minipigs; Cynomolgus Monkeys; Conclusions; References; Chapter 5: Standardized Scoring of Ocular Findings in the Context of Drug and Device Development Programs Introduction and BackgroundScoring of the Anterior Segment; The Standardization of Uveitis Nomenclature (SUN) System; The McDonald-Shadduck and Hackett-McDonald Systems; The Semi-quantitative Preclinical Ocular Toxicology Scoring (SPOTS) System: Anterior Segment; Pupillary Light Reflex (PLR); Conjunctiva; Corneal Opacity and Fluorescein Staining; Corneal Vascularization; Aqueous (Anterior Chamber) Flare; Aqueous (Anterior Chamber) Cell; Iris Involvement; Anterior Vitreous Cell; Lens Opacity; The SPOTS - Modified SUN System; Scoring of the Posterior Segment The National Eye Institute (NEI) Scoring System for Vitreous InflammationThe SPOTS Scoring System: Posterior Segment; Vitreous Haze; Degraded Fundus View; Retinal Perivascular Sheathing; Intravitreal Test Articles; Scoring System Modifications; Species-Specific Considerations for Ocular Scoring; Rodents (Mice and Rats); Rabbits; Dogs; Pigs; Nonhuman Primates; Conclusion; References; Index
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.7/1; Medicine; Ocular toxicology -- Congresses; Toxicology; Ophthalmology; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Medical -- Ophthalmology; Ophthalmology; Medical -- Pharmacology; Pharmacology; Electronic books
• Languages: English
• ISBNs: 9783319783642; 3319783645
• Related ISBNs: 9783319783635; 3319783637
• Notes: Note: Online resource; title from PDF title page (EBSCO, viewed September 6, 2018)
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.