Chemical Aspects of Photodynamic Therapy. (2014)

• Record Type: Book
• Further Information: Note: Raymond Bonnett.
• Authors: Bonnett, Raymond
• Contents: Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; Preface; Acronyms; Chapter 1: Introduction; 1.1 Definition of Area of Study; 1.2 Historical Aspects; 1.2.1 Vitamin D and Rickets; 1.2.2 Phototherapy of Psoriasis; 1.2.3 Neonatal Hyperbilirubinemia; 1.2.4 Cancer; Bibliography; Chapter 2: Physical Matters; 2.1 Light; 2.2 Light Sources; 2.2.1 Sunlight; 2.2.2 Incandescent Lamps; 2.2.3 Arc Lamps; 2.2.4 Light-emitting Diodes; 2.2.5 Lasers; 2.3 Light Absorption; 2.3.1 The Beer-Lambert Law; 2.3.2 Excitation; 2.3.2.1 Multiplicity; 2.3.2.2 Probability; 2.4 Emission 2.5 Jablonski Diagram2.6 Quantum Efficiency; 2.7 Intermolecular Electronic Excitation Transfer; 2.8 Singlet Oxygen Quantum Yields; Bibliography; Chapter 3: Singlet Oxygen; 3.1 General; 3.2 Generation of Singlet Oxygen; 3.2.1 Chemical Methods; 3.2.2 Physical Methods; 3.3 Chemical Reactions; 3.3.1 Alkenes -- the ""ene"" Reaction; 3.3.2 Electron-rich Alkenes; 3.3.3 Conjugated Dienes -- Diels-Alder Addition; 3.3.4 Miscellaneous Reactions; Bibliography; Chapter 4: Photodynamic Action; 4.1 Definition; 4.2 Discovery and Development; 4.3 Photodynamic Agents -- Structural Types 4.3.1 General Considerations4.3.2 Structural Types; 4.4 Mechanism of Photodynamic Action; 4.4.1 The Type I Mechanism -- Electron Transfer; 4.4.2 The Type II Mechanism -- Energy Transfer; 4.4.3 Distinguishing between Type I and Type II Photooxygenation Processes; 4.4.3.1 Tests for radical intermediates (Type I mechanism); 4.4.3.2 Tests for singlet oxygen (Type II mechanism); 4.4.4 The Overall Mechanistic Picture; Bibliography; Chapter 5: Some Other Examples of Photomedicine; 5.1 Introduction; 5.2 Sunscreens; 5.2.1 Sunlight and the Skin; 5.2.2 Artificial Sunscreens; 5.3 Skin Carcinogenesis 5.4 Phototherapy of Rickets (Osteomalacia)5.5 Psoriasis; 5.5.1 Photosensitisers for PUVA; 5.5.2 Mechanism; 5.6 Phototherapy of Neonatal Hyperbilirubinemia; 5.6.1 Photofragmentation; 5.6.2 Photoisomerisation / Photosolubilisation; 5.6.2.1 Photochemical configurational isomerisation (Photobilirubins I); 5.6.2.2 Photocyclisation (Photobilirubins If lumirubins); Bibliography; Chapter 6: The Chemistry of Haematoporphyrin Derivative (HpD); 6.1 Introduction; 6.2 Chemistry of HpD Stage I; 6.3 Chemistry of HpD Stage II; 6.4 Clinical Development; Bibliography Chapter 7: Second Generation Photosensitisers7.1 First Generation Photosensitisers; 7.1.1 Advantages; 7.1.2 Disadvantages; 7.2 Design Criteria for Second Generation Photosensitisers; 7.2.1 Dark Toxicity; 7.2.2 Composition; 7.2.3 Synthesis; 7.2.4 Solution Behaviour; 7.2.4.1 Tetraphenylporphyrin sulphonic acids; 7.2.4.2 Sulphonated metallophthalocyanines; 7.2.4.3 3-(1 -Alkyloxyethyl)-3-devinylpyropheophorbide a; 7.2.4.4 Spacing o f hydrophilic substituents on the hydrophobic framework; 7.2.5 Delivery Systems; 7.2.6 Photophysical Properties; 7.2.7 Red Absorption; Bibliography
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2014
• Extent: 1 online resource
• Subjects: 615.8/31; Pharmaceutical chemistry; Chemistry, Physical and theoretical; Chemistry, Physical and theoretical; Pharmaceutical chemistry; Electronic books
• Languages: English
• ISBNs: 9781482296952; 1482296950
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.