Handbook of Pharmaceutical Controlled Release Technology. (2000)

• Record Type: Book
• Further Information: Note: Donald L. Wise.
• Authors: Wise, Donald L
• Contents: Cover; Half Title; Title Page; Copyright Page; Preface; Contents; Part I: Polymers as Drug Delivery Carriers; 1: Hydrophilic Cellulose Derivatives as Drug Delivery Carriers: I nfluence of Substitution Type on the Properties of Compressed Matrix Tablets; I. INTRODUCTION; II. EXPERIMENTAL; A. Materials; B. Polymer Molecular Weight; Polymer Hydrophilicity; C. Polymer Hydrophilicity; D. Compact Preparation; E. Swelling and Front Movements; F. Drug Release and Polymer Dissolution; G. Polymer Disentanglement Concentration; III. POLYMER HYDROPHILICITY IV. EFFECT OF SUBSTITUTION TYPE ON MATRIX CHARACTERISTICSA. Swelling Characteristics; B. Polymer Erosion and Overlap/Disentanglement Concentration; C. Drug Release; IV. EFFECT OF DRUG LOADING ON MATRIX CHARACTERISTICS; V. EFFECT OF DRUG SOLUBILITY ON MATRIX CHARACTERISTICS; VI. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 2: Poly (Vinyl Alcohol) as aDrug Delivery Carrier; I. INTRODUCTION; II. BIOCOMPATSBILSTY ISSUES IN PVA-BASED SYSTEMS; III. POLY(VINYL ALCOHOL)-BASED CONTROLLED DRUG DELIVERY DEVICES; A. Swelling-Controlled Release Systems; B. Polymer Dissolution-Controlled Release Systems C. Crystal Dissolution-Controlled Release SystemsD. Modulated Drug Release Systems; IV. MATHEMATICAL MODELING; V. CONCLUSIONS; REFERENCES; 3: Development of Acrylate and Methacrylate Polymer Networks for Controlled Release by Photopolymerization Technology; I. STRUCTURE AND APPLICATIONS OF HIGHLY CROSSLINKEDPOLYMULTI(METH)ACRYLATES; II. PREPARATION OF POLYMULTI(METH)ACRYLATES; A. Diffusional Effects During Polymerization; B. Microgels and Structural Heterogeneity; C. Polymerization Kinetics; D. Rate Coefficients; III. NETWORK STRUCTURE AND MECHANICAL PROPERTIES; A. Rubber Elasticity Analysis B. Dynamic Mechanical BehaviorC. Volume Shrinkage and Aging; D. Glass Transition Temperatures; E. Control of the Structure of Highly Crosslinked Polymers; IV. EQUILIBRIUM SWELLING BEHAVIOR OF POLYMULTI(METH)ACRYLATES; V. KINETIC GELATION SIMULATIONS OF NETWORK STRUCTURE; VI. APPLICATIONS IN DRUG DELIVERY; ACKNOWLEDGMENTS; REFERENCES; 4: Smart Polymers for Controlled Drug Delivery; I. INTRODUCTION; II. PULSATILE SYSTEMS; A. Magnetically Stimulated Systems; B. Ultrasonically Stimulated Systems; C. Electrically Stimulated Systems; D. Photostimuiated Systems; III. SELF-REGULATED SYSTEMS A. Environmentally Responsive SystemsB. Systems Utilizing Specific Binding Interactions; C. Glucose-Responsive Insulin Delivery; IV. CONCLUDING REMARKS; REFERENCES; 5: Complexing Polymers in Drug Delivery; I. INTRODUCTION; II. COMPLEXATION BETWEEN POLY(METHACRYLIC ACID)/POLY(ETHYLENE GLYCOL); A. Complexation in Linear Polymers; B. Complexation in Polymer Networks; III. APPLICATIONS IN DRUG DELIVERY; IV. CONCLUSIONS; REFERENCES; 6: Polylactic and Polyglycolic Acidsas Drug Delivery Carriers; I. INTRODUCTION: A BRIEF HISTORY OF THE USE OF POLYLACTIC AND POLYGLYCOLIC ACIDS IN MEDICAL APPLICATIONS
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2000
• Extent: 1 online resource
• Subjects: 615/.19; Biomedical engineering; Biopharmaceutics; Drugs -- Design; Biomedical engineering; Biopharmaceutics; Drugs -- Design; Electronic books
• Languages: English
• ISBNs: 9781482289985; 1482289989
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.