Statistical Bases of Reference Values in Laboratory Medicine. (1995)

• Record Type: Book
• Further Information: Note: Eugene K. Harris, James C. Boyd.
• Authors: Harris, Eugene K; Boyd, James C
• Contents: Cover; Half Title; Series Page; Title Page; Copyright Page; Dedication; Preface; Table of Contents; Chapter 1 Some History of Reference Values; 1.1 Introduction; 1.2 Reference Ranges from Hospital Patients?; 1.3 Heterogeneity Among Reference Subjects; 1.4 Purposes of Reference Ranges for the Healthy; 1.5 Official Guidelines on Selection and Treatment of Reference Subjects; 1.6 Criticisms of the Normal Range; 1.7 Decision Levels and Patient Monitoring; Chapter 2 Calculating Reference Limits; 2.1 Introduction; 2.2 Nonparametric Estimation; 2.3 Efficiency of the Quantile Estimator 2.4 More Precise Nonparametric Estimates2.5 Parametric Estimation: Transformations to Normal Form; Appendix 2.1 BASIC Program for mle of Box-Cox Power Parameter.; Appendix 2.2 BASIC Program for mle of C in Transform log (x + C); Appendix 2.3 Data Sets: Alanine Aminotransferaseand Serum Haptoglobin; Chapter 3 Sample Sizes and Subgroups; 3.1 How Many Subjects?; 3.2 Individualizing the Reference Range; 3.3 How Many Subgroups?; 3.4 Outliers; 3.5 Transference of Reference Ranges; Appendix 3.1 BASIC Program for Sample Sizes Under Power Transform Appendix 3.2 Sample Sizes for log -- Normal DistributionsChapter 4 Multivariate Reference Regions and Indices; 4.1 Introduction; 4.2 The Bivariate Normal Distribution; 4.3 Multivariate Regions and Indices; 4.4 Transformation of Variables; 4.5 Multivariate Outliers; 4.6 Examples; Appendix 4.1 Eigenvalues, Eigenvectors, and Principal Components; Appendix 4.2 Data on Liver Enzymes: Alanine Transaminase; Chapter 5 Time-Dependent Reference Values; 5.1 Introduction; 5.2 Nonparametric Methods; 5.3 Parametric Methods; 5.4 Longitudinal Data; Conditional Changes Appendix 5.1 Age and PSA Measurements from a Study of 371Chapter 6 Comparison of Within-Subject and Among-Subjects Variances; 6.1 Introduction; 6.2 Homogeneity of Within-Subject Variances; 6.3 The Ratio of Average Within-Subject to Among-Subjects Variation; 6.4 Example; Appendix 6.1 Estimating Variance of True Within-Subject Variances; Appendix 6.2 Data Set: Serial Measurements of Immunoglobulin G (IgG); Chapter 7 Predictive Values for Monitoring Healthy Subjects and Patients; 7.1 Introduction; 7.2 Comparison of Two Serial Results; 7.3 Subject-Specific Predictive Values Appendix 7.1 BASIC Program for Reference Change LimitsChapter 8 Analytical Goals for Reference Values; 8.1 Introduction; 8.2 Analytical Goals for Group-Based Reference Ranges; 8.3 Analytical Goals in Detecting Patient Changes; 8.4 Analytical Goals Around Cutpoints of Risk; 8.5 Example; 8.6 Remarks; Chapter 9 Analytical Goals in Therapeutic DrugMonitoring; 9.1 Introduction; 9.2 Models for Analytical Goals in TDM; Chapter 10 Reference Values in the Future; 10.1 Introduction; 10.2 Electronic Medical Record; 10.3 Increasing Use of Automation; 10.4 Advances in Molecular Genetics
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 1995
• Extent: 1 online resource
• Subjects: 616.07/56; Biology -- Statistics; Medicine; Biology; Medicine; Electronic books; Statistics
• Languages: English
• ISBNs: 9781482273151; 1482273152
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.