Introductory Review on Sirtuins in Biology, Aging, and Disease. (2018)

• Record Type: Book
• Further Information: Note: Leonard Guarente, Raul Mostoslavsky, Aleksey Kazantsev.
• Editors: Guarente, Leonard; Mostoslavsky, Raul; Kazantsev, Aleksey
• Contents: 1. Early Sirtuin Research 1991-2000 2. Regulation of sirtuins by systemic NAD+ biosynthesis 3. NAD modulation - biology and therapy 4. The enzymatic activity of sirtuins 5. Molecular mechanisms of Sirtuin activation and inhibition 6. Pharmacological approaches for modulating sirtuins 7. Mitochondrial Sirtuins 8. Biological Roles and Activities for Mitochondrial Sirtuins 9. The multitasking roles of the mammalian deacetylase SIRT6 10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond 11. Sirtiuns and Carcinogenesis 12. Roles for sirtuins in cardiovascular biology 13. Sirtuins in Brain Biology and Disease
• Publisher Details: Academic Press
• Publication Date: 2018
• Extent: 1 online resource (220 pages)
• Languages: English
• ISBNs: 9780128135006
• Related ISBNs: 012813500X
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.