Handbook of brain tumor chemotherapy, molecular therapeutics, and immunotherapy. ([2018])

• Record Type: Book
• Further Information: Note: Edited by Herbert B. Newton, MD, FAAN.
• Editors: Newton, Herbert B
• Contents: Front Cover; Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy; Copyright; Contents; Contributors; Section I: Pharmacological and Clinical Applications; Chapter 1: Overview of Brain Tumor Epidemiology and Histopathology; Epidemiology of Brain Tumors; Pathology of Central Nervous System Tumors-Introduction; Pathology of Tumors of Neuroepithelial Origin; Pathology of Tumors of the Meninges; Pathology of Primary CNS Lymphoma; Pathology of Intracranial Germ Cell Tumors; References; Chapter 2: Clinical Pharmacology of Brain Tumor Chemotherapy; Introduction Pharmacology and Drug DistributionSupportive Therapeutics; Corticosteroids; Gastric Acid Inhibitors; Anticonvulsants; Delivery of Chemotherapeutic Agents; Continuous Infusion; Intra-Arterial; Interstitial; Blood-Brain Barrier Disruption; Chemotherapeutic Agents; Alkylating Agents; Nitrogen Mustards; Nitrosoureas; Procarbazine; Platinum Compounds; Temozolomide; Natural Products; Vinca Alkaloids; Pyrimidine Analogs; Purine Analogs; Folic Acid Analogs; Topoisomerase Inhibitors; Camptothecin Derivatives; Conclusions; References Chapter 3: Antiepileptic Drugs and Chemotherapy: Potential Interactions and Impact on Treatment of Patients With CancerIntroduction; Mechanism of Interaction Between AEDs and CTAs; Phase I Interactions; Phase II Interactions; Other Potential Mechanisms of AED/CTA Interactions; The Impact of AED-CTA Interactions; EIAED Effects on Targeted Therapies; AED Selection in Cancer Patients; Expected Enzyme Induction Profile of New AEDs; Changing From One AED to Another; Conclusions; Disclosure; References; Chapter 4: Brain Tumor Models for Cancer Therapy; Rat Brain Tumor Models Blood-Brain Barrier in Rat Brain Tumor ModelsLocal Delivery in Rat Brain Tumor Models; Immunological Approaches in Rat Brain Tumor Models; Chemotherapy and Boron Neutron Capture in Rat Brain Tumor Models; Human Brain Tumor Xenograft Models; Blood-Brain Barrier in Human Brain Tumor Xenograft Models; Local Delivery in Human Brain Tumor Xenograft Models; Chemotherapy in Human Brain Tumor Xenograft Models; Angiogenesis in Brain Tumor Models; References; Chapter 5: Genomics and Proteomics in Neuro-Oncology; Introduction; RNA Expression Analysis; DNA Methylation Analysis; Disease Proteomics Preanalytic and Bioinformatic ConsiderationsTumor Expression Profiling: Medulloblastoma; Molecular Basis and Genomic Subclassification of Medulloblastomas; Tumor Expression Profiling: Glioma; Drug Discovery and Targeting; Summary; References; Further Reading; Chapter 6: Chemotherapy Resistance; Common Chemotherapeutic Agents in Gliomas; DNA Repair and Chemotherapy Resistance; Methylguanine Methyltransferase; Histone Modification; MicroRNAs and Long Noncoding RNAs; DNA Mismatch Repair; Nucleotide and Base Excision Repair; Detoxification and Other Mechanisms of Resistance
• Publisher Details: London San Diego, CA : Academic Press, an imprint of Elsevier
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.99/481; Brain -- Tumors -- Chemotherapy -- Handbooks, manuals, etc; Molecular genetics -- Handbooks, manuals, etc; Molecular biology -- Handbooks, manuals, etc; Immunotherapy -- Handbooks, manuals, etc; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; MEDICAL / Chemotherapy; MEDICAL / Oncology; Electronic books
• Languages: English
• ISBNs: 9780128121016; 0128121017
• Related ISBNs: 9780128121009
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed April 4, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.