Zika virus and diseases : from molecular biology to epidemiology /: from molecular biology to epidemiology. (2018)

• Record Type: Book
• Further Information: Note: Suzane R. da Silva, Fan Cheng, Shou-Jiang Gao.
• Authors: Silva, Suzane R. da; Cheng, Fan; Gao, Shou-Jiang
• Contents: Preface; List of Abbreviations Chapter 1: The history of ZIKV discovery; 1.1 ZIKV isolation from monkeys and mosquitos; 1.2 ZIKV infection in humans; 1.3 ZIKV infection spread to other hosts and regions; 1.4 Cross-paths between ZIKV and other flaviviruses; References Chapter 2: ZIKV: From silent to epidemic; 2.1 Outbreak in Yap Island (2007); 2.2 Outbreak in French Polynesia (2013); 2.3 How did ZIKV reach Brazil?; 2.4 Outbreak in Brazil (2015); 2.5 ZIKV spread through South, Central and North Americas; References Chapter 3: ZIKV Transmission and Prevention; 3.1 Modes of Transmission; 3.2 Prevention; References Chapter 4: Association with Guillain-Barré syndrome and microcephaly; 4.1 Association with neurological disorders; References Chapter 5: ZIKV animal models; 5.1 Animal models: Embryonated hen eggs; 5.2 Animal models: Landrace piglet; 5.3 Animal models: Mice; 5.4 Animal model – non-human primate; References Chapter 6: Biology of ZIKV; 6.1 Structural and physical properties of ZIKV virion; 6.2 Binding and entry; 6.3 Genome structure; 6.4 Translation and proteolytic processing; 6.5 Features of the non-structural proteins; 6.6 RNA replication; 6.7 Features of the structural proteins; 6.8 Virus assembly and release from virus-infected cells; References Chapter 7: Zika virus (ZIKV) strains and lineages; 7.1 East and West African lineage; 7.2 Africa vs. Asian/American lineage; References Chapter 8: ZIKV-host interactions; 8.1 Systematic studies to identify ZIKV affected functions and pathways; 8.2 Induction and dysregulation of innate immune responses during ZIKV infection; 8.3 Induction of cell death and apoptosis by ZIKV; 8.4 Induction of autophagy by ZIKV; 8.5 Dysregulation of cell cycle and induction of abnormal mitosis by ZIKV; References Chapter 9: Inhibitors of ZIKV replication and infection; 9.1 Drugs that lead to the destruction of ZIKV virions; 9.2 Drugs that inhibit ZIKV entry and endocytosis; 9.3 Drugs that target ZIKV NS2B-NS3 protease activity; 9.4 Drugs that target ZIKV NS5 RNA-dependent RNA polymerase activity; 9.5 Neutralizing antibodies that target ZIKV structural protein; 9.6 Drugs that inhibit ZIKV infection by targeting host machinery; 9.7 Drugs that show neuroprotective activity but do not suppress ZIKV replication; 9.8 Other drugs that inhibit ZIKV infection identified from a screening of FDA-approved drugs; References Chapter 10: Long-term care and Perspectives; 10.1 Prenatal care and diagnosis of abnormal fetus development; 10.2 Long-term care for patients affected by ZIKV; 10.3 Assistance to families with children affected by ZIKV; 10.4 Perspectives; References Index
• Edition: 1st
• Publisher Details: Chichester : Wiley Blackwell
• Publication Date: 2018
• Extent: 1 online resource, illustrations
• Subjects: 616.9185; Zika virus infection
• Languages: English
• ISBNs: 9781119408666; 9781119408659
• Related ISBNs: 9781119408642
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.