Fundamentals of Receptor, Enzyme, and Transport Kinetics (1993). (2017)

• Record Type: Book
• Authors: Matthews, John C
• Contents: Cover; Title Page; Copyright Page; Preface; The Author; Acknowledgment; Table of Contents; Part I: Receptors; Chapter 1 Introduction to Receptors; I. Receptor-Ligand Complexes; II. Affinity, Intrinsic Activity, and Effect; III. Receptor Stimulation and Physiological Effect; IV. Fundamentals of Receptor-Ligand Interaction; V. Antagonists and Activators; Chapter 2 Simple Receptor-Ligand Interactions; I. Ligand Binding; II. RL Lifetimes and Reaction Rate Constants; III. Chemical Equilibrium; IV. Equilibrium and Affinity Constants; V. Receptor-Ligand Interaction Energies. VI. The Langmuir Binding IsothermVII. The Practical Meaning of Affinity; VIII. Fractional Receptor Occupancy; IX. Linear Transformations; A. Double-Reciprocal or Lineweaver-Burk Equation; B. The Rosenthal-Scatchard Equation; C. The Eadie-Hofstee Equation; D. The Woolf Equation; X. Weighting Errors; Chapter 3 Overview of Techniques for Direct Measurement of Receptor-Ligand Interactions; I. Receptor Preparations; II. Choosing Receptor Ligands and Radioisotopes; III. Quantification of Radioactivity; IV. Equilibrium and Dynamic Binding Measurements; V. Fast and Slow Receptor-Ligand Interactions. VI. General Considerations in Receptor Binding MethodsA. Relationship between Receptor and Ligand Concentrations; B. Nonspecific Binding; C. Affinity; D. Choice of Isotope for Radiolabeling; E. Weighting Errors Inherent in the Use of Radioisotopes; VII. Calorimetry; Chapter 4 Receptor-Ligand Interactions That Generate Proportional Physiological Effects; I. Relationship between Ligand Binding and Effect; II. The Value pL[sub(2)]; III. pH Equations and Receptor-Ligand Interactions; IV. Relative Intrinsic Activity. Chapter 5 Overview of Mechanisms for Coupling of Receptor-Agonist Interactions with Physiological EffectsI. Introduction; II. Ion Channel-Linked Signal Transduction; III. Cyclic Nucleotide-Linked Signal Transduction; A. Stimulatory Receptors; B. Inhibitory Receptors; IV. Phosphatidyl Inositol-Linked Signal Transduction; V. Steroid Receptors; Chapter 6 Overview of Techniques for Measuring Receptor-Agonist Interactions Through Their Physiological Effects; I. Introduction; II. Effects on Whole Animals; III. Isolated Organs and Tissues; IV. Tissue Slices, Cell Cultures, and Membrane Vesicles. V. Receptor-Effector Systems at the Molecular LevelChapter 7 Receptor-Ligand Interactions that are Disproportionate with Their Physiological Effects; I. Introduction; II. Spare Receptors; III. Homotropic Cooperativity and the Hill Equation; IV. Discrepancies in and Alternatives for the Hill Equation; V. Physiological Advantages of Homotropic Cooperativity; A. Hemoglobin; B. Calmodulin; VI. Heterotropic Cooperativity; VII. Receptor Desensitization; Chapter 8 Antagonism; I. Introduction; II. Types of Antagonism; A. Chemical Antagonism; B . Physical Antagonism; C. Functional Antagonism.
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 615.7; Physiology; BIOSCIENCEnetBASE; SCI-TECHnetBASE; BIOMEDICALSCIENCEnetBASE; LIFESCIENCEnetBASE; STMnetBASE; Biological transport; Cell receptors; Enzyme kinetics; Ligand binding (Biochemistry); Pharmacokinetics; Electronic books
• Languages: English
• ISBNs: 9780203713433; 0203713435; 9781351364584; 1351364588; 9781351364577; 9781351364560; 1351364561
• Related ISBNs: 135136457X; 1138105511; 9781138105515
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.