Handbook of growth factors. General basic aspects / Volume 1, (2017)

• Record Type: Book
• Further Information: Note: Enrique Pimentel.
• Authors: Pimentel, Enrique
• Contents: Cover; Half Title; Title Page; Copyright Page; Contents; Chapter 1 Regulation of Cell Functions; I. Introduction; II. The Cell Cycle; A. Phases of the Cell Cycle; B. Regulation of the Cell Cycle; C. Cellular Senescence; D. Apoptosis; E. Cellular Immortalization; III. Regulation of Cell Proliferation and Differentiation; A. Role of Growth Factors in Developmental Processes; B. Regulation of Homeobox-Containing Genes; C. Competence and Progression Factors; D. Cellular Responses to Growth Factors; E. Regulation of Differentiated Functions by Growth Factors; F. Growth Factor-Like Proteins. G. Proliferation-Associated Cellular ProteinsH. Mechanisms of Regulation of Cell Proliferation by Growth Factors; 1. Gene Expression During the Cell Cycle; 2. Cyclins; 3. The cdc2 and cdk2 Protein Kinases; 4. Transcription Factors; 5. Heat Shock Proteins; I. Differentiation-Inducing Factors; 1. Osteogenin; 2. Preadipocyte-Stimulating Factor; 3. Leukemia-Related Differentiation Inducers; 4. Leukemia Inhibitory Factor; 5. Other Differentiation Inducers; 6. Mechanisms of Cell Differentiation; J. Differentiation-Inhibiting Factors; K. Growth-Inhibiting Factors; 1. GIFs Produced by Normal Cells. 2. GIFs Produced by Neoplastic C ells3. Physiological Role of GIFs; 4. Role of GIFs in Oncogenesis; IV. Growth Factors as Mediators of Hormone Action; A. Growth Hormone; 1. The Growth Hormone Receptor; 2. Somatomedins; B. Thyroid Hormone; 1. Thyroid Hormone Receptors; 2. Growth Factors as Mediators of Thyroid Hormone Action; C. Steroid Hormones; 1. Steroid Hormone Receptors; 2. Growth Factors as Mediators of Steroid Hormone Action; References; Chapter 2 Growth Factor Receptors; I. Introduction; II. Growth Factor Receptors; A. Regulation of Receptor Expression; B. Receptor Phosphorylation. C. Mobility and Internalization of Surface ReceptorsD. Receptor Expression in Neoplastic Cells; References; Chapter 3 Postreceptor Mechanisms of Growth Factor Action; I. Introduction; II. Mediators and Modulators of Growth Factor Action; A. Prostaglandins; 1. Physiological Role of Prostaglandins; 2. Cellular Mechanisms of Action of Prostaglandins; 3. Role of Prostaglandins in Tumors; B. Leukotrienes; C. Poly amines; 1. Regulation of Ornithine Decarboxylase; 2. Mechanisms of Action of Polyamines; 3. Role of Poly amines in Oncogenesis; III. Ion and pH Changes; A. Ion Fluxes and Cytoplasmic pH. B. Mechanism of Na[sub(+)]/H[sub(+)] Exchange RegulationC. Influence of Mitogens, Hormones, and Growth Factors; D. Regulation of Cell Cycle-Associated Events; E. Influence of Oncogenes; F. Expression of a Transformed Phenotype; G. Role of Magnesium; References; Chapter 4 Cyclic Nucleotides; I. Introduction; II. Cyclic AMP and the Adenylyl Cyclase System; A. The Adenylyl Cyclase System; 1. The Adenylyl Cyclase Family; 2. Regulation of the Adenylyl Cyclase System; 3. Role of cAMP in Hormone and Growth Factor Action; 4. Role of cAMP in the Regulation of Gene Expression.
• Publisher Details: Boca Raton, FL : CRC Press
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 612.6; Genetics; Endocrinology; Cell Biology; BIOSCIENCEnetBASE; SCI-TECHnetBASE; LIFESCIENCEnetBASE; MEDICINEnetBASE; STMnetBASE; Growth factors; Electronic books
• Languages: English
• ISBNs: 9780203712603; 0203712609; 9781351363181; 1351363182; 9781351363174; 1351363174
• Related ISBNs: 1138105759; 9781138105751
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.