Neuronal cell death and repair. (1993)

• Record Type: Book
• Further Information: Note: Edited by A. Claudio Cuello.
• Editors: Cuello, A. C (A. Claudio)
• Contents: Front Cover; Neuronal Cell Death and Repair; Copyright Page; List of Contributors; Preface; Table of Contents; SECTION I: Cellular and Molecular Mechanisms for Neuronal Cell Death; CHAPTER 1. An Introduction to Apoptosis; 1. Introduction; Acknowledgements; References; CHAPTER 2. Apoptosis; 1. Introduction; 2. Classical apoptosis; 3. Mechanisms of apoptosis and programmed cell death; 4. Apoptosis, differentiation and atrophy; 5. Conclusion; References; CHAPTER 3. Molecular mechanism of programmed cell death in the developing nervous system; 1. Introduction. 2. Control of neuronal death during development3. Molecular mechanism of neuronal death; 4. Regulation of trophic factor dependence; 5. Concluding comments; Acknowledgments; References; CHAPTER 4. Neurotrophic factors and apoptosis in the nervous system; 1. Developmental neuronal death in vertebrates as a stochastic process regulated by trophic factors; 2. Apoptosis as a possible mode of neuronal cell death; 3. Cultures of PC12 cells and sympathetic neurons as model systems to study neuronal cell death caused by withdrawal of neurotrophic factors. 4. Correlation of endonuclease activity with neuronal cell death caused by trophic factor deprivation5. Apoptotic neuronal death after insult; 6. Role of macromolecular synthesis in neuronal death and survival; 7. Signal transduction pathways mediating neuronal survival; 8. Summary, conclusions and further prospects; References; CHAPTER 5. The microtubule cytoskeleton in neuronal development and degeneration; 1. The MAP proteins in morphogenesis and neuronal degeneration; 2. The MAPI protein family; 3. The MAP2 Protein Family; 4. The function and dysfunction of the TAU protein family. 5. The significance of MAPs phosphorylation states in neuronal degenerationReferences; CHAPTER 6. Molecular biology and pathology of Alzheimer's disease; 1. Introduction; 2. The amyloid concept; 3. ß A4 amyloid protein in the aetiology of Alzheimer's disease; 4. The nature of the ""Alzheimer-specific"" ßA4 amyloid protein; 5. Synthetic ßA4 amyloid; 6. ßA4 amyloid protein deposition at synapses; 7. ßA4 protein as biological marker of preclinical Alzheimer's disease; 8. The family of ßA4 amyloid protein precursors (APP); 9. Processing of APP to ßA4; 10. Function of APP. 11. Regulation of the APP gene12. Mechanism and role of amyloid deposition in Alzheimer's disease; Acknowledgments; References; SECTION II: Chemically Induced Neuronal Cell Death; CHAPTER 7. Excitatory amino acids and free radicals in the genesis of ischemic neuronal death; 1. Introduction; 2. Free radicals release EAA; 3. A model of retina ischemia: possible actions of free radicals; 4. Thiokynurenates antagonize neuronal death by acting as NMDA antagonists and as inhibitors of lipoperoxidation.; Acknowledgements; References; CHAPTER 8. Cell death: a tough business; 1. Introduction.
• Publisher Details: Amsterdam : Elsevier
• Publication Date: 1993
• Extent: 1 online resource (xv, 317 pages), illustrations
• Subjects: 571.9/36; Nervous system -- Degeneration; Nervous system -- Regeneration; Cell death; Neurons; Brain -- Cytology; Brain -- Cytology; Cell death; Nervous system -- Degeneration; Nervous system -- Regeneration; Neurons; Nervenzelle; Regenerationsfähigkeit; Neuronen; Regeneratie; Degeneratie; Electronic books
• Languages: English
• ISBNs: 9781483290263; 1483290263
• Related ISBNs: 0444814701; 9780444814708
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.