Hematology : basic principles and practice /: basic principles and practice. (©2013)

• Record Type: Book
• Further Information: Note: [edited by] Ronald Hoffman [and others].
• Other Names: Hoffman, Ronald, 1945-
• Contents: Anatomy and physiology of the gene -- Genomic approaches to hematology -- Regulation of gene expression, transcription, splicing, and RNA metabolism -- Protein synthesis, processing, and trafficking -- Protein architecture: relationship of form and function -- Signaling transduction and regulation of cell metabolism -- Pharmacogenomics and hematologic diseases -- Hematopoietic stem cell biology -- Hematopoietic microenvironment -- Cell adhesion -- Hematopoietic cell trafficking and chemokines -- Dynamic interactions between hematopoietic stem and progenitor cells and the bone marrow: current biology of stem cell homing and mobilization -- Vascular growth in heatlh and disease -- Principles of cytokine signaling -- Control of cell division -- Cell death -- Overview and compartmentalization of the immune system -- B-cell development -- T-cell immunity -- Natural killer cell immunity -- Dendritic cell biology -- Complement and immunoglobulin biology -- Tolerance and autoimmunity -- Biology of erythropoiesis, erythroid differentiation, and maturation -- Granulocytopoiesis and monocytopoiesis -- Thrombocytopoiesis -- Inherited forms of bone marrow failure -- Aplastic anemia -- Paroxysmal nocturnal hemoglobinuria -- Acquried disorders of red cell, white cell, and platelet production -- Pathobiology of the human erythrocyte and its hemoglobins -- Approach to anemia in the adult and child -- Pathophysiology of iron homeostasis -- Disorders of iron homeostasis: iron deficiency and overload -- Anemia of chronic diseases -- Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias -- Megaloblastic anemias -- Thalassemia syndromes -- Pathobiology of sickle cell disease -- Sickle cell disease: clinical features and management -- Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias -- Red blood cell enzymopathies -- Red blood cell membrane disorders -- Autoimmune hemolytic anemia -- Extrinsic nonimmune hemolytic anemias -- Neurotrophilic leukocytosis, neurotropenia, monocytosis, and monocytopenia -- Lymphocytosis, lymphocytopenia, hypergammaglobulinemia, and hypogammaglobulinema -- Disorders of phagocyte function -- Congenital disorders of lymphocyte function -- Histiocytic disorders -- Lysosomal storage diseases: perspectives and principles -- Infections mononucleosis and other Epstein-Barr virus-associated diseases -- Progress in the classification of myeloid neoplasms: clinical implications -- Conventional and molecular cytogenetic basis of hemotologic malignancies -- Radiation therapy in the treatment of hematologic malignancies -- Pathobiology of acute myeloid leukema -- Clinical mainfestations and treatment of acute myeloid leukemia -- Myelodysplastic syndromes: biology and treatment -- Allogenic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults. Acute myeloid leukemia in children -- Myelodysplastic and myeloproliferative neoplasms in children -- Pathobiology of acute lymphoblastic leukemia -- Clinical manifestations and treatment of acute lymphoblastic leukemia in children -- Acute lymphoblastic leukemia in adults -- Chronic myeloid leukemia -- The polycythemias -- Essential thrombocythemia -- Primary myelofibrosis -- Eosinophilia, eosinophil-associated diseases, chronic eosinophil leukemia, and the hypereosinophilic syndromes -- Mast cellls and systemic mastocytosis -- Pathologic basis for the classification of non-hodgkin and hodgkin lymphomas -- Origin of hodgkin lymphoma -- Hodgkin lymphoma: clinical manifestations, staging, and therapy -- Origin of non-Hodgkin lymphoma -- Chronic lymphocytic leukemia -- Hairy cell leukemia -- Clinical manifestations and treatment of marginal zone lymphomas (extranodal/malt, splenic, and nodal) -- Clinical manifestations, staging, and treatment of follicular lymphoma -- Mantle cell lymphoma -- Diagnosis and treatment of diffuse large b-cell lymphoma and Burkitt lymphoma -- Virus-associated lymphoma -- Malignant lymphomas in childhood -- T-cell lymphomas -- Plasma cell neoplasms -- Waldenström macroglobulinemia and lymphoplasmacytic lymphoma -- Immunoglobulin light-chain amyloidosis (primary amyloidosis) -- Clinical approach to infections in the compromised host -- Indwelling access devices -- Nutritional issues in patients with hematologic malignancies -- Psychosocial aspects of hematologic disorders -- Pain management and antiemetic therapy in hematologic disorders -- Palliative care -- Late complications of hematologic diseases and their therapies -- Overview and historical perspecitve of current cell-based therapies -- Practical aspects of hematologic stem cell harvesting and mobilization -- Preclinical process of cell-based therapies -- Graft engineering and cell processing -- Principles of cell-based genetic therapies -- Mesenchymal stromal cells -- T-cell therapy of hematologic diseases -- Natural killer cell-based therapies -- Dendritic cell therapies -- Overview of hematopoietic stem cell transplantation -- Indications and outcome of allogeneic hematopoietic cell transplantation for hematologic malignancies in adults -- Unrelated donor hematopoietic cell transplantation -- Haploidentical hematopoietic cell transplantation -- Unrelated donor cord blood transplantation for hematologic malignancies -- Graft-versus-host disease and graft-versus-leukemia responses -- Complications after hematopoietic stem cell transplantation -- Human blood group antigens and antibodies -- Principles of red blood cell transfusion -- Principles of platelet transfusion therapy -- Human leukocyte antigen and human neutrophil antigen systems -- Principles of neutrophil (granulocyte) transfusions -- Principles of plasma transfusion: plasma, cryoprecipitate, albumin, and immunoglobulins. Preparation of plasma-derived and recombinant human plasma proteins -- Transfusion therapy for coagulation factor deficiencies -- Hemapheresis -- Transfusion reactions to blood and cell therapy products -- Transfusion-transmitted diseases -- Transfusion medicine in hematopoietic stem cell and solid organ transplantation -- Pediatric transfusion medicine -- Overview of hemostasis and thrombosis -- The blood vessel wall -- Megakaryocyte and platelet structure -- Molecular basis for platelet function -- Molecular basis of blood coagulation -- Regulatory mechanisms in hemostasis -- Clinical approach to the patient with bleeding or bruising -- Laboratory evaluation of hemostatic and thrombotic disorders -- Acquired disorders of platelet function -- Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura -- Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution -- Heparin-induced thrombocytopenia -- Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome -- Hemophilia A and B -- Inhibitors in hemophilia A and B -- Rare coagulation factor deficiencies -- Structure, biology, and genetics of von willebrand factor -- Disseminated intravascular coagulation -- Hypercoagulable states -- Antiphospholipid syndrome -- Venous thromboembolism -- Mechanical interventions in arterial and venous thrombosis -- Atherothrombosis -- Stroke -- Acute coronary syndromes -- Atrial fibrillation -- Peripheral artery disease -- Antithrombotic drugs -- Disorders of coagulation in the neonate -- Hematologic changes in pregnancy -- Hematologic manifestations of childhood illness -- Hematologic manifestations of liver disease -- Hematologic manifestations of systemic disease: renal disease -- Hematologic manifestations of cancer -- Integrative therapies in patients with hematologic diseases -- Hematologic manifestations of HIV/AIDS -- Hematologic aspects of parasitic diseases -- Hematologic problems in the surgical patient: bleeding and thrombosis -- The spleen and its disorders -- Hematology in aging -- Resources for the hematologist: interpretive comments and selected reference values for neonatal, pediatric, and adult populations.
• Edition: 6th ed
• Publisher Details: Philadelphia, PA : Saunders/Elsevier
• Publication Date: 2013
• Copyright Date: 2013
• Extent: 1 online resource (xxiii, 2270 pages), illustrations (some color)
• Subjects: 616.1/5; Blood -- Diseases; Hematology; Hématologie; Sang -- Maladies; MEDICAL -- Hematology; Blood -- Diseases; Hematology; Hematologic Diseases -- diagnosis; Hematologic Diseases -- therapy; Blood Physiological Phenomena; Electronic books
• Languages: English
• ISBNs: 9781455740413; 1455740411
• Related ISBNs: 9781437729283; 1437729282
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.