Insulin-like growth factors in health and disease. (2012)

• Record Type: Book
• Further Information: Note: Guest editors, Claire M. Perks, Jeff M.P. Holly.
• Other Names: Perks, Claire M; Holly, Jeff M. P
• Contents: Front Cover; Endocrinology and Metabolism Clinics of North America; Copyright Page; Contributors; Table of Contents; Forthcoming Issues; Foreword; Preface; Chapter 1. Insulin-Like Growth Factor-1 Physiology: Lessons from Mouse Models; INTRODUCTION; IGF-1 SYSTEM IN NORMAL PHYSIOLOGY; REFERENCES; Chapter 2. Insulin-Like Growth Factor Physiology: What we have Learned from Human Studies; BACKGROUND; SYSTEMIC MODUS OPERANDI; DISTINCTIONS BETWEEN HUMANS AND EXPERIMENTAL MODELS; IGF-II AND METABOLISM; IGF-I AND NUTRITIONAL PROGRAMMING; AGING AND THE ELDERLY; REFERENCES. Chapter 3. The Insulin-Like Growth Factors and Growth Disorders of ChildhoodINTRODUCTION; GROWTH DISORDERS CAUSED BY GH/IGF PATHWAY DEFECTS; IGF IN THE CIRCULATION; TREATMENT OF PRIMARY IGFD; FUTURE DEVELOPMENTS; REFERENCES; Chapter 4. The Insulin-Like Growth Factors in Adipogenesis and Obesity; EXPERIMENTAL/IN VITRO EVIDENCE; CLINICAL CONSIDERATIONS; OPEN QUESTIONS; REFERENCES; Chapter 5. Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle. INSULIN-LIKE GROWTH FACTOR AND MAMMALIAN TARGET OF RAPAMYCIN IN SKELETAL MUSCLE HEALTH: THE WHYS AND THE WHEREFORESMUSCLE IGFs AND NUTRITION: SUBSTRATES AND SIGNALING; MUSCLE IGFs AND EXERCISE: MAY THE FORCE BE WITH YOU; OH MY: MYOSTATIN AND FOLLISTATIN SIGNAL VIA THE IGF-IR AND mTOR; GLUCOCORTICOIDS AND ANDROGENS: A TALE OF TWO STEROID HORMONES IN THE CONTROL OF MUSCLE MASS; IMMOBILIZED MUSCLE: A CAST OF CHARACTERS INVOLVED IN MUSCLE ATROPHY; ALCOHOL INDUCES LEUCINE AND IGF-I RESISTANCE IN SKELETAL MUSCLE; SUMMARY; REFERENCES. Chapter 6. The Insulin-Like Growth Factor System in Bone: Basic and Clinical ImplicationsINTRODUCTION; IGF-I REGULATORY SYSTEM AND BONE; ANIMAL STUDIES; ROLE OF THE IGFBPs IN THE SKELETON; ROLE OF IGF-I IN THE SKELETON; SUMMARY; REFERENCES; Chapter 7. The Insulin-Like Growth Factor System in Cancer; THE INSULIN-LIKE GROWTH FACTOR SYSTEM AND CANCER RISK; THE IGF SYSTEM IN CELLULAR PROLIFERATION AND SURVIVAL; THE INSULIN RECEPTOR AND HYBRID RECEPTORS; SIGNAL TRANSDUCTION CROSS-TALK; IGF-BINDING PROTEINS; SPECIFIC CANCERS; SUMMARY; REFERENCES. Chapter 8. Insulin-Like Growth Factors in Normal and Diseased KidneyINTRODUCTION; PHYSIOLOGY OF THE IGF SYSTEM IN THE KIDNEY; THE IGF SYSTEM IN SELECTED RENAL DISEASES; THERAPEUTIC IMPLICATIONS; SUMMARY; REFERENCES; Chapter 9. Insulin-Like Growth Factors in the Peripheral Nervous System; INTRODUCTION; THE IGF SYSTEM IN THE PNS; IGFs IN PNS DISEASES; SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 10. Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases; INTRODUCTION; IGF-1, AGING, AND NEURODEGENERATION; ROLE OF IGF-1 IN PATHOLOGIC CASCADES ASSOCIATED WITH NEURODEGENERATION.
• Publisher Details: Philadelphia : Saunders
• Publication Date: 2012
• Extent: 1 online resource (xvi, [231]-473 pages), illustrations, portraits
• Subjects: 618.3; Somatomedin; Growth factors; MEDICAL -- Gynecology & Obstetrics; Growth factors; Somatomedin; Electronic books
• Languages: English
• ISBNs: 9781455742776; 1455742775
• Related ISBNs: 9781455738564
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.