Hematology/oncology clinics of North America. Complement-mediated hemolytic anemias / Volume 29, Number 3, ([2015])

• Record Type: Book
• Other Titles: Complement-mediated hemolytic anemias
• Further Information: Note: Editor, Robert A. Brodsky ; consulting editors, George P. Canellos, H. Franklin Bunn.
• Editors: Brodsky, Robert A
• Contents: Cover image; Title page; Table of Contents; Copyright; Contributors; Consulting Editors; Editor; Authors; Forthcoming Issues; Forthcoming Issues; Recent Issues; Preface: Complement in Health and Disease; Complement; Key points; Activation of the complement system; Regulation of the complement system; Functions of the complement system; Hemolysis from ABO Incompatibility; Key points; History; ABO antigen expression and biochemistry; Pathophysiology; Settings of ABO incompatible reactions; Clinical management; Summary; Warm Autoimmune Hemolytic Anemia; Key points; Introduction; Diagnosis. EtiologyAssociated conditions; Treatment; Summary/Discussion; Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia; Key points; Introduction; Cold agglutinins; Chronic cold agglutinin disease; Secondary cold agglutinin syndrome; Paroxysmal Cold Hemoglobinuria; Key points; Introduction; Mechanism of hemolysis; Prevalence and clinical presentation; Laboratory testing; Treatment; Summary; Paroxysmal Nocturnal Hemoglobinuria; Key points; Introduction; The pathophysiology of the complement dysregulation in paroxysmal nocturnal hemoglobinuria. The complement proteins in paroxysmal nocturnal hemoglobinuriaParoxysmal nocturnal hemoglobinuria as a hemolytic anemia; Paroxysmal nocturnal hemoglobinuria as a disease of marrow failure; Paroxysmal nocturnal hemoglobinuria as a disease of thrombosis; Paroxysmal nocturnal hemoglobinuria and consequences of nitric oxide; Diagnosis and classification of paroxysmal nocturnal hemoglobinuria; Current therapies for paroxysmal nocturnal hemoglobinuria directed against complement; Predictors of response to eculizumab therapy. Cure for paroxysmal nocturnal hemoglobinuria: hematopoietic stem cell transplantationFuture therapies for paroxysmal nocturnal hemoglobinuria directed against complement; Summary; Congenital CD59 Deficiency; Key points; Introduction; Function of CD59; Genetic basis of CD59 deficiency; Clinical symptoms of CD59 deficiency; Laboratory diagnosis of CD59 deficiency; CD59 as a blood group; CD59 deficiency and treatment; Summary. Ultralarge Von Willebrand Factor-Induced Platelet Clumping and Activation of the Alternative Complement Pathway in Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic SyndromesKey points; Thrombotic microangiopathies (TMAs); Overview of the thrombotic microangiopathies; Overview of the alternative complement pathway; Ultralarge von Willebrand factor multimers and initiation of the alternative complement pathway; Generation of terminal complement complexes; Ultralarge von Willebrand factor multimers and alternative complement pathway activation in the thrombotic microangiopathies.
• Publisher Details: Philadelphia, Pennsylvania : Elsevier
• Publication Date: 2015
• Extent: 1 online resource (233 pages)
• Subjects: 616.1/52079; Hemolytic anemia -- Immunological aspects; Complement (Immunology); Hemolytic anemia, Autoimmune; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Electronic books
• Languages: English
• ISBNs: 9780323388917; 0323388914
• Notes: Note: Online resource; title from digital title page (viewed on June 08, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.