Iron disorders. (2014)

• Record Type: Book
• Further Information: Note: Editors, Matthew M. Heeney, Alan R. Cohen ; contributors, Edouard Bardou-Jacquet [and fourteen others].
• Editors: Heeney, Matthew M; Cohen, Alan R
• Other Names: Bardou-Jacquet, Edouard contributor.
• Contents: Front Cover; Iron Disorders; Copyright; Contributors; Contents; Hematology/Oncology Clinics Of North America; Preface; Diagnostic Evaluation of Hereditary Hemochromatosis (HFE and Non-HFE); Key points; Introduction; Iron Metabolism; Iron absorption and export; Hepcidin; Hepcidin regulation; Iron Overload; Hepcidin deficiency; Ferroportin disease; Penetrance; Diagnostic Work-up; Patient history; Physical examination; Organs Involved in Hereditary Hemochromatosis; Liver disease; Bones and joints; Heart; Pancreas; Pituitary; Clinical Presentation According the Type of Hereditary Hemochromatosis. Hepcidin deficiencyFerroportin disease; Types of hereditary hemochromatosis and genetic testing; The Different Types of Hereditary Hemochromatosis; Type 1 (HFE related) hemochromatosis; Type 2 (HJV and HAMP related) hemochromatosis; Type 3 (TFR2 related) hemochromatosis; Type 4 hemochromatosis: ferroportin disease; Other rare iron overload diseases; Genetic Testing; Increased transferrin saturation; Normal or low transferrin saturation; Summary; References; Iron-Refractory Iron Deficiency Anemia (IRIDA); Key points; Introduction; Clinical presentation; Genetics; Differential diagnosis. TreatmentAcknowledgments; References; Sideroblastic Anemia; Key points; General overview; Diagnosis; Nonsyndromic CSAs; Syndromic CSAs; Undefined CSAs; Acquired Clonal SAs; Acquired Metabolic SAs; Disease courses and treatment options; Nonsyndromic CSA; Syndromic CSA; Acquired Clonal SA; Splenectomy in SA; Iron overload; Summary; References; Anemia of Inflammation; Key points; Clinical presentation; Definitions; Related Conditions; Diagnosis; Diagnostic Challenges; Prevalence; Pathophysiology; Overview of the Causative Factors; Erythrocyte Destruction; Hypoferremia. Mechanisms of iron toxicity in transfusional overloadDistribution and consequences of TIO; Iron Distribution and Consequences in Thalassemia Major; Iron Distribution and Consequences in SCD; Iron Distribution in Other Forms of TIO; Mechanisms underlying distribution of transfused iron; References; Transfusional Iron Overload and Iron Chelation Therapy in Thalassemia Major and Sickle Cell Disease; Key points; Introduction; Blood transfusions; TM; SCD; Erythrocytapheresis in SCD; Iron overload; Does Iron Overload Differ Between SCD and TM?; Iron-induced Organ Damage in SCD.
• Publisher Details: Philadelphia, Pennsylvania : Elsevier
• Publication Date: 2014
• Copyright Date: 2014
• Extent: 1 online resource (161 pages), illustrations, tables
• Subjects: 616.152; Anemia; Iron -- Metabolism; Iron -- Metabolism -- Disorders; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Anemia; Iron -- Metabolism; Iron -- Metabolism -- Disorders; Electronic books
• Languages: English
• ISBNs: 9780323299404; 0323299407
• Related ISBNs: 9780323299220
• Notes: Note: Includes bibliographical references at the end of each chapters and index.; Note: Online resource; title from PDF title page (ebrary, viewed October 9, 2014).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.