Clinical biochemistry : metabolic and clinical aspects /: metabolic and clinical aspects. (2014)

• Record Type: Book
• Uniform Title: Clinical biochemistry (Churchill Livingstone)
• Further Information: Note: Edited by William J. Marshall, Marta Lapsley, Andrew P. Day, Ruth M. Ayling.
• Editors: Marshall, William J, 1944 April 1; Lapsley, Marta; Day, Andrew P, 1961-; Ayling, Ruth M
• Contents: Front Cover; Clinical Biochemistry: Metabolic and clinical aspects; Copyright; Contents; Preface; Contributors; Chapter 1: Uses of biochemical data in clinical medicine; Introduction; Specific uses of biochemical tests; Diagnosis; Management; Assessment of disease severity; Prognosis; Monitoring the progression of disease; Screening; Population screening; Selective screening; Individual screening; Other uses of biochemical investigations; Conclusion; Further reading; Chapter 2: Acquisition and interpretation of biochemical data; Introduction; The Test Request; Factors Affecting Test Results. Preanalytical factorsTechnical factors; Biological factors; Endogenous factors; Age; Sex; Ethnic origin; Body mass; Exogenous factors; Time-dependent changes; Stress; Posture; Food intake; Drugs; Other factors; Intrinsic biological variation; Analytical range; Accuracy and bias; Analytical factors; Precision; Specificity and interference; Practicalities: what is desirable performance?; Analytical goals; Postanalytical factors; Interpretation of Results; Normal and abnormal; The meaning of normal; Reference values; Problems with reference intervals. Comparison of observed results with reference limitsComparison of results with previous values; The Predictive Value of Tests; Introduction; Definitions; Example; Prevalence and predictive value; Practical applications of the predictive value model; Receiver operating characteristic curves; Likelihood ratios; Conclusion; Acknowledgement; Further reading; Chapter 3: Quality aspects of laboratory medicine; Introduction; What is quality?; Quality standards; Quality assurance; Regulation of laboratories; Quality management systems; Personnel; Premises and environment; Information systems. Evaluation and auditClinical quality indicators; Clinical effectiveness; Key performance indicators; Demand management; Evidence-based clinical biochemistry; Point-of-care testing; Conclusion; Further Reading; Chapter 4: Sodium, water and potassium; Physiology; Introduction; Extracellular fluid and sodium; Renal control of sodium output; Intrinsic renal control of tubular reabsorption of sodium; Renin-angiotensin-aldosterone axis; Natriuretic peptides; Sodium appetite; Intracellular fluid and water; Control of renal water output; Osmoregulation; Non-osmotic control of arginine vasopressin. Renal responsiveness to arginine vasopressinControl of water intake; Osmoregulation; Non-osmotic control of thirst; Extracellular fluid, intracellular fluid and potassium; Extracellular and intracellular fluid distribution of potassium; Renal control of potassium output; Intrinsic tubular control; Aldosterone; Disorders of sodium metabolism; Sodium deficiency; Clinical presentation; Causes of sodium deficiency; Extrarenal sodium loss; Primary renal sodium loss; Secondary renal sodium loss; Laboratory investigation of sodium deficiency; Management of sodium deficiency; Sodium excess.
• Publisher Details: Edinburgh New York : Churchill Livingstone/Elsevier
• Publication Date: 2014
• Copyright Date: 2014
• Extent: 1 online resource (x, 932 pages)
• Subjects: 616.07/56; Clinical biochemistry; Biochemistry; Metabolism -- physiology; Clinical biochemistry; Electronic books
• Languages: English
• ISBNs: 9780702054785; 9780702051401; 0702051403
• Related ISBNs: 070205478X
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from digital title page (viewed on July 31, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.