Drug hepatotoxicity. (2014)

• Record Type: Book
• Further Information: Note: Edited by Nicholaos Pyrsopoulos.
• Editors: Pyrsopoulos, Nicholaos
• Contents: Front Cover; Clinics in Liver Disease: Drug Hepatotoxicity; Copyright Page; Contributors; Table of Contents; CLINICS IN LIVER DISEASE; Preface; Chapter 1. Mechanisms of Drug-induced Liver Injury; KEYWORDS; KEY POINTS; NECROSIS, APOPTOSIS, AND NECROPTOSIS; THE INVOLVEMENT OF REACTIVE METABOLITES; INVOLVEMENT OF STRESS SIGNALING; THE INVOLVEMENT OF MITOCHONDRIAL DYSFUNCTION; THE INVOLVEMENT OF MITOCHONDRIAL ADAPTATION; THE ROLE OF ADAPTIVE IMMUNITY AND INNATE IMMUNITY IN DILI; SUMMARY; REFERENCES; Chapter 2. Drug-Induced Cholestasis; KEYWORDS; KEY POINTS; INTRODUCTION; EPIDEMIOLOGY. RISK FACTORSPATHOGENESIS; ASSOCIATION OF CAUSALITY; CLASSIFICATION OF DRUG-INDUCED CHOLESTASIS; ACUTE CHOLESTATIC DILI; CHRONIC CHOLESTATIC DILI; TREATMENT; PROGNOSIS; SUMMARY; REFERENCES; Chapter 3. Drug-Induced Steatohepatitis; KEYWORDS; KEY POINTS; DEFINITION OF NAFLD; DIAGNOSING DRUG-INDUCED STEATOHEPATITIS; PATHOGENESIS OF DRUG-INDUCED STEATOHEPATITIS; PATHOLOGIC SPECTRUM OF DRUG-INDUCED STEATOSIS AND STEATOHEPATITIS; MANAGEMENT OF PATIENTS WITH DRUG-INDUCED STEATOHEPATITIS; SUMMARY; REFERENCES; Chapter 4. Histopathologic Manifestations of Drug-induced Hepatotoxicity; KEYWORDS. KEY POINTSINTRODUCTION; HEPATOCELLULAR INJURY PATTERN; CHOLESTATIC INJURY PATTERN; STEATOSIS AND STEATOHEPATITIS PATTERN; GRANULOMA AND GRANULOMATOUS HEPATITIS; VASCULAR INJURY PATTERNS; CYTOPLASMIC INCLUSIONS, LIPIDOSIS, AND PIGMENTS; DRUG-INDUCED HEPATIC NEOPLASMS; SUMMARY; REFERENCES; Chapter 5. Clinical Manifestations and Treatment of Drug-induced Hepatotoxicity; KEYWORDS; KEY POINTS; EPIDEMIOLOGY; TERMINOLOGY; DIAGNOSIS; MANAGEMENT; REFERENCES; Chapter 6. Drug-induced Acute Liver Failure; KEYWORDS; KEY POINTS; BACKGROUND; ACETAMINOPHEN-RELATED ALF; IDIOSYNCRATIC DRUG-RELATED LIVER INJURY. OVERALL MANAGEMENTTRANSPLANTATION AND PROGNOSIS; GENOMICS AND THE FUTURE; SUMMARY; REFERENCES; Chapter 7. Acetaminophen-related Hepatotoxicity; KEYWORDS; KEY POINTS; INTRODUCTION; EPIDEMIOLOGY; PHARMACOLOGY AND HEPATOTOXICITY; FACTORS INFLUENCING APAP-RELATED HEPATOTOXICITY; CLINICAL MANIFESTATIONS; GENERAL APPROACH AND DIAGNOSTIC TOOLS; MANAGEMENT OF APAP OVERDOSE; REFERENCES; Chapter 8. Hepatotoxicity of Antibiotics: A Review and Update for the Clinician; KEYWORDS; KEY POINTS; INTRODUCTION; INCIDENCE OF ANTIBIOTIC DILI; INFECTIONS CAUSING JAUNDICE. PHARMACOGENOMICS, BIOMARKERS, AND ANTIBIOTIC DILIINDIVIDUAL ANTIMICROBIAL AGENTS: WHAT'S NEW?; ANTITUBERCULOSIS DRUGS; ANTIFUNGAL AGENTS; ANTIVIRAL AGENTS; ANTIPROTOZOAL AND ANTHELMINTIC AGENTS; ANTIBIOTIC USE IN CIRRHOSIS (INCLUDING TREATMENT OF SPONTANEOUS BACTERIAL PERITONITIS); SUMMARY; REFERENCES; Chapter 9. Nonsteroidal Anti-Inflammatory Drug-Induced Hepatoxicity; KEYWORDS; KEY POINTS; INTRODUCTION; DRUG-INDUCED LIVER INJURY; SEVERE HEPATOTOXICITY ASSOCIATED WITH NSAIDS; EPIDEMIOLOGY OF NSAID-INDUCED HEPATOTOXICITY; SUMMARY; REFERENCES.
• Publisher Details: Amsterdam : Elsevier
• Publication Date: 2014
• Extent: 1 online resource
• Subjects: 616.362071; Hepatotoxicology; Drugs -- Toxicology; Liver -- Effects of drugs on; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Electronic books
• Languages: English
• ISBNs: 9780323261074; 0323261078
• Related ISBNs: 9780323261067; 032326106X
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.