Mitochondrial dysfunction by drug and environmental toxicants. (2018)

• Record Type: Book
• Further Information: Note: Edited by Yvonne Will, James A. Dykens.
• Editors: Will, Yvonne; Dykens, James Alan, 1951-
• Contents: Volume 1 List of Contributors xvii Foreword xxix Part 1 Basic Concepts 1 1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug?]Induced Mitochondrial Toxicity 3; Gavin P. McStay 2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity 15; Kathleen M. Giacomini and Huan?]Chieh Chien 3 Structure–Activity Modeling of Mitochondrial Dysfunction 25; Steve Enoch, Claire Mellor, and Mark Nelms 4 Mitochondria?]Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic Induced Toxicity 35; Haider Raza, F. Peter Guengerich, and Narayan G. Avadhani Part 2 Organ Drug Toxicity: Mitochondrial Etiology 47 5 Mitochondrial Dysfunction in Drug?]Induced Liver Injury 49; Annie Borgne?]Sanchez and Bernard Fromenty 6 Evaluating Mitotoxicity as Either a Single or Multi?]Mechanistic Insult in the Context of Hepatotoxicity 73; Amy L. Ball, Laleh Kamalian, Carol E. Jolly, and Amy E. Chadwick 7 Cardiotoxicity of Drugs: Role of Mitochondria 93; Zoltan V. Varga and Pal Pacher 8 Skeletal Muscle Mitochondrial Toxicity 111; Eric K. Herbert, Saul R. Herbert, and Karl E. Herbert 9 Manifestations of Drug Toxicity on Mitochondria in the Nervous System 133; Jochen H. M. Prehn and Irene Llorente?]Folch 10 Nephrotoxicity: Increasing Evidence for a Key Role of Mitochondrial Injury and Dysfunction and Therapeutic Implications 169; Ana Belén Sanz, Maria Dolores Sanchez?]Niño, Adrian M. Ramos, and Alberto Ortiz 11 Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds 185; Sandra Amaral, Renata S. Tavares, Sara Escada?]Rebelo, Andreia F. Silva, and João Ramalho?]Santos Part 3 Methods to Detect Mitochondrial Toxicity: In Vitro, Ex Vivo, In Vivo, Using Cells, Animal Tissues, and Alternative Models 205 12 Biological and Computational Techniques to Identify Mitochondrial Toxicants 207; Robert B. Cameron, Craig C. Beeson, and Rick G. Schnellmann 13 The Parallel Testing of Isolated Rat Liver and Kidney Mitochondria Reveals a Calcium?]Dependent Sensitivity to Diclofenac and Ibuprofen 217; Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt, and Hans Zischka 14 In Vitro Methodologies to Investigate Drug?]Induced Toxicities 229; Rui F. Simões, Teresa Cunha?]Oliveira, Cláudio F. Costa, Vilma A. Sardão, and Paulo J. Oliveira 15 Combined Automated Measurement of Respiratory Chain Complexes and Oxidative Stress: A First Step to an Integrated View of Cell Bioenergetics 249; Marc Conti, Thierry Delvienne, and Sylvain Loric 16 Measurement of Mitochondrial Toxicity by Flow Cytometry 265; Padma Kumar Narayanan and Nianyu Li 17 MitoChip: A Transcriptomics Tool for Elucidation of Mechanisms of Mitochondrial Toxicity 275; Varsha G. Desai, and G. Ronald Jenkins 18 Using 3D Microtissues for Identifying Mitochondrial Liabilities 295; Simon Messner, Olivier Frey, Katrin Rössger, Andy Neilson, and Jens M. Kelm 19 Toward Mitochondrial Medicine: Challenges in Rodent Modeling of Human Mitochondrial Dysfunction 305; David A. Dunn, Michael H. Irwin, Walter H. Moos, Kosta Steliou, and Carl A. Pinkert 20 Measurement of Oxygen Metabolism In Vivo 315; M. P. J. van Diemen, R. Ubbink, F. M. Münker, E. G. Mik, and G. J. Groeneveld 21 Detection of Mitochondrial Toxicity Using Zebrafish 323; Sherine S. L. Chan and Tucker Williamson 22 MiRNA as Biomarkers of Mitochondrial Toxicity 347; Terry R. Van Vleet and Prathap Kumar Mahalingaiah 23 Biomarkers of Mitochondrial Injury After Acetaminophen Overdose: Glutamate Dehydrogenase and Beyond 373; Benjamin L. Woolbright and Hartmut Jaeschke 24 Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction 383; Richard D. Beger, Sudeepa Bhattacharyya, Pritmohinder S. Gill, and Laura P. James 25 Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug?]Induced Toxicity Studies 395; Afshan N. Malik 26 Predicting Off?]Target Effects of Therapeutic Antiviral Ribonucleosides: Inhibition of Mitochondrial RNA Transcription 407; Jamie J. Arnold and Craig E. Cameron 27 Imaging of Mitochondrial Toxicity in the Kidney 419; Andrew M. Hall, Joana R. Martins, and Claus D. Schuh 28 Imaging Mitochondrial Membrane Potential and Inner Membrane Permeability 429; Anna?]Liisa Nieminen, Venkat K. Ramshesh, and John J. Lemasters 29 Quantifying Skeletal Muscle Mitochondrial Function In Vivo by 31P Magnetic Resonance Spectroscopy 443; Graham J. Kemp Volume 2 List of Contributors xiii Foreword xxv Part 4 Reports from the Clinic 457 30 Statin and Fibrate?]Induced Dichotomy of Mitochondrial Function 459; Viruna Neergheen, Alex Dyson, Luke Wainwright, and Iain P. Hargreaves 31 Friend or Foe: Can Mitochondrial Toxins Lead to Similar Benefits as Exercise? 475; Sofia Annis, Adeel Safdar, Eduardo Biala, Ayesha Saleem, Housaiyin Li, Priya Gandhi, Zoe Fleischmann, Carmen Castaneda?]Sceppa, Jonathan L. Tilly, Dori C. Woods, and Konstantin Khrapko 32 Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction 487; Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos, and Félix Carvalho 33 Drug?]Induced Mitochondrial Toxicity during Pregnancy 509; Diana Luz Juárez-Flores, Ana Sandra Hernández, Laura Garcia, Mariona Guitart?]Mampel, Marc Catalan?]Garcia, Ingrid Gonzalez?]Casacuberta, Jose César Milisenda, Josep Maria Grau, Francesc Cardellach, Constanza Morén, and Glòria Garrabou 34 Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy 521; Antoni Noguera?]Julian, Eneritz Velasco?]Arnaiz, and Clàudia Fortuny 35 Drug?]Induced Mitochondrial Cardiomyopathy and Cardiovascular Risks in Children 529; Neha Bansal, Mariana Gerschenson, Tracie L. Miller, Stephen E. Sallan, Jason Czachor, Hiedy Razoky, Ashley Hill, Miriam Mestre, and Steven E. Lipshultz 36 Role of Mitochondrial Dysfunction in Linezolid?]Induced Lactic Acidosis 547; Alessandro Santini, Dario Ronchi, Daniela Piga, and Alessandro Protti 37 Metformin and Lactic Acidosis 559; Jean?]Daniel Lalau 38 Lessons Learned from a Phase I Clinical Trial of Mitochondrial Complex I Inhibition 563; Cecilia C. Low Wang, Jeffrey L. Galinkin, and William R. Hiatt 39 Pharmacological Activation of Mitochondrial Biogenesis for the Treatment of Various Pathologies 569; Whitney S. Gibbs, Natalie E. Scholpa, Craig C. Beeson, and Rick G. Schnellmann 40 Mitochondrial Toxicity Induced by Chemotherapeutic Drugs 593; Luciana L. Ferreira, Ana Raquel Coelho, Paulo J. Oliveira, and Teresa Cunha?]Oliveira Part 5 Environmental Toxicants and Mitochondria 613 41 The Mitochondrial Exposome 615; Douglas I. Walker, Kurt D. Pennell, and Dean P. Jones 42 Central Mitochondrial Signaling Mechanisms in Response to Environmental Agents: Integrated Omics for Visualization 639; Young?]Mi Go, Karan Uppal, and Dean P. Jones 43 Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans 655; Laura L. Maurer, Anthony L. Luz, and Joel N. Meyer 44 Persistent Organic Pollutants, Mitochondrial Dysfunction, and Metabolic Syndrome 691; Hong Kyu Lee and Youngmi Kim Pak 45 Cigarette Smoke and Mitochondrial Damage 709; Jalal Pourahmad, Marjan Aghvami, Mohammad Hadi Zarei, and Parvaneh Naserzadeh Index 727
• Edition: 1st
• Publisher Details: Hoboken, New Jersey : John Wiley & Sons, Inc
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 615.902; Drugs -- Toxicology; Mitochondrial pathology
• Languages: English
• ISBNs: 9781119329749; 9781119329732
• Related ISBNs: 9781119329701
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.