Drug Selectivity : An Evolving Concept in Medicinal Chemistry /: An Evolving Concept in Medicinal Chemistry. (2017)

• Record Type: Book
• Further Information: Note: Norbert Handler, Helmut Buschmann, Raimund Mannhold, Jörg Holenz.
• Editors: Handler, Norbert; Buschmann, Helmut; Mannhold, Raimund; Holenz, Jörg
• Contents: PART I. INTRODUCTION; Polypharmacology in Drug Discovery; ; PART II. SELECTIVITY OF MARKTETED DRUGS; Kinase Inhibitors; New Indications for Marketed Drugs; Discovery Technologies of New Indications; ; PART III. FIXED-DOSE COMBINATIONS; The Growing Market of Fixed-Dose Combinations; ; PART IV. UNSELECTIVE DRUGS IN DRUG DISCOVERY; The Growing Importance of Individualising Drugs; Drug Discovery Strategies for the Generation of Multi-Target Ligands against Neglected Tropical Diseases; Designing-In Approach; The Linker Approach (Drug-Conjugates); Merged Multiple Ligands; Pharmacophore Generation of Multiple Ligands; Cellular Assays; ; PART V. THERAPEUTIC AREAS FOR DESIGNED MULTIPLE LIGANDS; 5HT Transporter-Based Multiple Ligands for Depression; Multiple Ligands Targeting the Angiotensin System for Hypertension; PPAR-Based Multiple Ligands for Metabolic Disease; Antibiotics; Multiple Ligands in Cancer Therapy; Multiple Ligands in Neurodegenerative Diseases
• Edition: 1st
• Publisher Details: Wiley-VCH
• Publication Date: 2017
• Extent: 1 online resource (1100 pages)
• Languages: English
• ISBNs: 9783527674404
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.