Metal nanoparticles : synthesis and applications in pharmaceutical sciences /: synthesis and applications in pharmaceutical sciences. (2017)

• Record Type: Book
• Further Information: Note: Edited by Sreekanth Thota, Debbie C. Crans.
• Editors: Thota, Sreekanth; Crans, Debbie Catharina
• Contents: 1 Introduction 1; Sreekanth Thota and Debbie C. Crans 1.1 History of Metal Complexes 1 1.1.1 Introduction 1 1.1.2 Metal Complexes 1 1.1.3 Metal Complexes in Medicine 2 1.2 Nanotechnology 2 1.2.1 Introduction 2 1.2.2 Development of Nanotechnology 2 1.2.3 Nanotechnology in Medicine 3 1.3 Nanoparticles 4 1.3.1 Introduction 4 1.3.2 Development of Nanoparticles 5 1.3.2.1 Liposome-Based Nanoparticles 5 1.3.2.2 Polymeric Nanoparticles 5 1.3.2.3 Metal Nanoparticles 5 1.3.3 Nanoparticles in Science and Medicine 6 1.4 Nanotechnology-Supported Metal Nanoparticles 7 Acknowledgment 7 References 7 2 Methods for Preparation of Metal Nanoparticles 15; Siavash Iravani 2.1 Introduction 15 2.2 Methods for Preparation ofMetallic NPs 15 2.2.1 Physical and Chemical Methods 15 2.2.2 Green and Bio-based Strategies 19 2.3 Conclusion 24 References 24 3 Metal Nanoparticles as Therapeutic Agents: A Paradigm Shift in Medicine 33; Mahendra Rai, Dipali Nagaonkar, and Avinash P. Ingle 3.1 Introduction 33 3.2 Metal Nanoparticles in Diagnostics 35 3.2.1 Nanoparticles as Biolabels 35 3.2.2 Nanoparticulate Detection of Proteins 35 3.2.3 Nanobiosensing 36 3.2.4 In vivo Imaging 37 3.3 Advanced Drug Delivery 38 3.4 Nanoparticle-Mediated Gene Transfer 39 3.5 Nanotechnology in RegenerativeTherapies 41 3.5.1 Tissue Engineering and Implants 41 3.5.2 Bone Regeneration Materials 41 3.5.3 In Dentistry 42 3.5.4 CellTherapy 43 3.6 Nanoparticles–Essential Oils Combination Against Human Pathogens 43 3.7 Conclusion 44 Acknowledgment 44 References 44 4 Nanoparticles for Imaging 49; Yerra Rajeshwar 4.1 Introduction 49 4.2 Nanoparticles 49 4.3 Nanoparticles as Diagnostic Probes 52 4.3.1 Nanoparticles as Blood Pool Contrast Agents 52 4.3.2 Imaging for MPS 54 4.3.3 Cell Labeling and Tracking 57 4.3.4 Labeling Implants, Transplants, and Grafts 60 4.3.5 Nano- and Microparticles for Molecular Imaging 62 4.4 Nanoparticle-BasedTheranostics 67 4.4.1 Nanoparticles for Imaging-Guided Interventions 67 4.4.2 Nano- or Microparticles for Imaging-Guided Hyperthermia Treatment 67 4.4.3 Imaging-Guided Drug Delivery 69 4.5 Conclusion 70 References 71 5 Soft-Oxometalates: A New State of Oxometalates and Their Potential Applications as Nanomotors 83; Apabrita Mallick and Soumyajit Roy 5.1 Introduction to Soft-Oxometalates (SOMs) 83 5.1.1 Classification of Soft-Oxometalates 84 5.1.1.1 Spontaneously Formed Soft-Oxometalates 84 5.1.1.2 Designed Soft-Oxometalates 84 5.2 Application of Soft-Oxometalates 85 5.2.1 Control of Morphology of SOMs 85 5.2.2 SOMs in Catalysis 86 5.2.3 SOMs in Patterning 86 5.3 Active Nano/micro Motors 89 5.3.1 CatalyticMotors 89 5.3.2 Magnetically Propelled Motors 89 5.3.3 Electrically Propelled Motors 90 5.3.4 Light Driven Motors 90 5.3.5 Ultrasonically Driven Motors 90 5.4 Micro-Optomechanical Movement (MOM) in Soft-Oxometalates 90 5.5 Autonomous Movements Induced in Heptamolybdate SOMs 92 5.6 SOMs asWater Oxidation Catalysts 94 5.7 Conclusion 95 Acknowledgment 95 References 95 6 Medicinal Applications of Metal Nanoparticles 101; Ayan K. Barui, Rajesh Kotcherlakota, and Chitta R. Patra 6.1 Overview 101 6.2 Introduction and Background 101 6.2.1 History of Medicinal Use of Metals, Metal Ions, and Complexes 103 6.2.2 Nanotechnology and Nanomedicine 104 6.2.3 Application of Disease-Specific Nanomedicine 105 6.2.4 Importance of Metal Nanoparticles in Biology 105 6.3 Biomedical Applications of Metal Nanoparticles 106 6.3.1 Delivery of Biomolecules Using Metal Nanoparticles 107 6.3.1.1 Drug Delivery 107 6.3.1.2 Nucleic Acid Delivery 112 6.3.1.3 Immunological Molecule Delivery 113 6.3.2 Anticancer Activities of Metal Nanoparticles 114 6.3.3 AntiangiogenicTherapy Using Metal Nanoparticles 116 6.3.4 Proangiogenic Properties of Metal Nanoparticles 117 6.3.5 Metal Nanoparticles in Bioimaging 119 6.3.6 Biosensing Applications of Metal Nanoparticles 120 6.3.7 Antimicrobial Activity of Metal Nanoparticles 122 6.3.8 Metal Nanoparticles in Neurodegenerative Diseases 124 6.3.9 Metal Nanoparticles in Tissue Engineering 126 6.3.10 Metal Nanoparticles in Diabetes 126 6.3.11 Metal Nanoparticles for Retinal Disorder 127 6.3.12 Anti-Inflammatory Effects of Metal Nanoparticles 127 6.3.13 Biologically Synthesized Nanoparticles for Biomedical Applications 128 6.4 Pharmacokinetics of Metal Nanoparticles 129 6.5 Status of Metal Nanoparticles in Clinical Study 131 6.6 Future Prospect of Metal Nanoparticles in Medicine 132 Acknowledgment 133 Abbreviations 133 References 135 7 Metal Nanoparticles in Nanomedicine: Advantages and Scope 155; Tapan K. Sau, Arunangshu Biswas, and Parijat Ray 7.1 Introduction 155 7.1.1 Therapeutic Use of Metals: Historical Perspective 155 7.1.2 Nanomedicines and Metals 156 7.2 Advantages Associated with Metal Nanosystems 157 7.2.1 Metals as Nanosystems 158 7.2.1.1 Small Size and Large Surface Area-to-Volume Ratio 158 7.2.1.2 Shape and Morphology Dependence 159 7.2.2 Varieties of Metal Nanoparticles, Synthesis, and Fabrication Techniques 159 7.2.3 Inertness, Biocompatibility, and Ease of Surface Modifications 160 7.2.4 Optical Properties: Localized Surface Plasmon Resonance (LSPR) 162 7.2.5 Large Scattering and Absorption Cross Sections and Photothermal Effects 166 7.2.6 Enhanced Local Electromagnetic Field: Surface-Enhanced Spectroscopies 167 7.3 Applications and Scope 169 7.3.1 Targeted Drug Delivery and Controlled Release 169 7.3.2 Photothermal and Photodynamic Therapies and Cancer Treatment 173 7.3.3 Antimicrobial andWound Healing Effects 175 7.3.4 Clinical Diagnostics 177 7.3.4.1 Medical Imaging 178 7.4 Concluding Remarks 185 Acknowledgments 185 References 185 8 Applications of Metal Nanoparticles in Medicine/Metal Nanoparticles as Anticancer Agents 203; Wenjie Mei and QiongWu 8.1 Advantages of Metal Nanoparticles 203 8.1.1 Stability and Homogeneity 203 8.1.2 Luminescence Property 204 8.1.3 Biocompatibility 204 8.1.4 Metabolic Pathways 204 8.2 Metal Nanoparticles as Anticancer Agents 205 8.3 Gold Nanoparticles 205 8.3.1 AuNPs as Therapeutic Agents 206 8.3.1.1 AuNPs in Plasmonic PhotothermalTherapy 206 8.3.1.2 AuNPs in Photodynamic Therapy 207 8.3.1.3 AuNPs as aTherapeutic Agent 207 8.3.2 AuNPs as Drug Carriers 208 8.3.2.1 Targeted Delivery of Anticancer Drugs 208 8.3.2.2 Delivery of Genes 209 8.3.3 AuNPs in Cancer Imaging 209 8.4 Silver Nanoparticles (AgNPs) 210 8.4.1 Synthesis of AgNPs 210 8.4.1.1 Chemical Methods 210 8.4.1.2 Physical Methods 210 8.4.1.3 Biological Methods 210 8.4.2 AgNPs as Inhibitor in Chemotherapy 211 8.4.2.1 AgNPs as Promising Inhibitor Against Tumor 211 8.4.3 AgNPs as Drug Carrier 212 8.4.4 AgNPs in Cellular Imaging and Clini
• Edition: 1st
• Publisher Details: Weinheim : Wiley-VCH
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 620.5; Nanoparticles; Nanoparticles -- Therapeutic use; Metals; Drugs
• Languages: English
• ISBNs: 9783527807086; 9783527807062; 9783527807079
• Related ISBNs: 9783527339792
• Notes: Note: Description based on CIP data; resource not viewed.
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