Chemical biology of natural products. ([2017])

• Record Type: Book
• Further Information: Note: [edited by] David J. Newman, Gordon M. Cragg, and Paul Grothaus.
• Other Names: Newman, David J, 1939-; Cragg, Gordon M. L; Grothaus, Paul
• Contents: Cover; Half Title ; Title Page ; Copyright Page ; Table of Contents ; Preface ; Editors ; Contributors ; Chapter 1: Microbial Genome Mining for Natural Product Drug Discovery ; 1.1 Introduction ; 1.1.1 Importance of Natural Products and the Issue of Rediscovery 1.1.2 Genome Mining Enhances Discovery and Circumvents Rediscovery 1.1.3 Scope of the Chapter ; 1.2 The New Central Dogma of Genome Mining ; 1.2.1 What Is Genome Mining and Why Is It Important? ; 1.2.2 What Are the Drivers for Successful Genome Mining? ; 1.2.2.1 Primary Drivers 1.2.2.1.1 Microbes Gifted for Natural Product Biosynthesis 1.2.2.1.1.1 Actinomycetes ; 1.2.2.1.1.2 Other Culturable Bacteria ; 1.2.2.1.1.3 Culturable Archaea ; 1.2.2.1.1.4 Uncultured Bacteria and Archaea ; 1.2.2.1.1.5 Historical Record ; 1.2.2.1.2 DNA Sequencing Technology 1.2.2.1.3 Methods to Activate Expression of Cryptic SM Pathways 1.2.2.1.3.1 Fermentation Optimization ; 1.2.2.1.3.2 Genetic Manipulations ; 1.2.2.2 Secondary Drivers ; 1.2.2.2.1 Bioinformatics ; 1.2.2.2.1.1 antiSMASH ; 1.2.2.2.1.2 PRISM ; 1.2.2.2.1.3 MIBiG ; 1.2.2.2.1.4 IMG-ABC 1.2.2.2.2 Metabolomics 1.2.2.2.3 Enzyme Structural Biology and Function ; 1.2.3 Strategies and Tactics for Genome Mining ; 1.2.3.1 Mining Individual Microbes ; 1.2.3.1.1 Streptomyces avermitilis ; 1.2.3.1.2 Streptomyces coelicolor ; 1.2.3.1.3 Streptomyces ambofaciens
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 615.3/21; Pharmacognosy; Natural products; Natural products; Pharmacognosy; MEDICAL / Pharmacology; Electronic books
• Languages: English
• ISBNs: 9781315117089; 1315117088; 1351643282; 9781351643283
• Related ISBNs: 9781439841938; 1439841934
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.