Fundamentals of intracellular calcium. (2017)

• Record Type: Book
• Further Information: Note: Anthony K. Campbell.
• Authors: Campbell, Anthony K
• Contents: About the author Preface Glossary of acronyms About the Companion Web site Chapter 1 Calcium is special 1.1 Calcium and everyday events 1.2 Discovery of calcium 1.3 A natural history of calcium 1.3.1 Calcium by the sea 1.3.2 Calcium in your wake-up call 1.4 The elements of life 1.5 The natural occurrence of calcium 1.5.1 Isotopes of calcium 1.5.2 Geology of calcium 1.5.3 Calcium outside cells 1.5.4 Calcium inside cells 1.6 Requirement of cells for Ca2+ 1.6.1 Calcium in external fluids 1.6.2 Requirement of cell types for calcium 1.7 The four biological roles of calcium 1.7.1 Structural 1.7.2 Electrical across biological membranes 1.7.3 Extracellular cofactor 1.7.4 Intracellular regulator 1.8 The puzzle about Ca2+ inside cells 1.9 How important intracellular calcium has been in science 1.10 Darwin and intracellular Ca2+ 1.11 The scene set 1.12 ‘Ja Kalzium, das ist alles!’ 1.13 Calcium – the fundamentals 1.14 Recommended reading Chapter 2 Intracellular calcium – principles 2.1 Ca2+ and the concept of cell signalling 2.1.1 Primary signals and intracellular Ca2+ 2.1.2 The source of intracellular Ca2+ 2.2 The problem 2.3 Some key questions 2.3.1 Question 1 – what is the primary stimulus and secondary regular(s) 2.3.2 Question 2 – what is the intracellular signal 2.3.3 Question 3 – how do the secondary regulators work 2.4 The types of intracellular Ca2+ signal 2.4.1 Category of cell based on the Ca2+ signal 2.4.2 Types of Ca2+ signal 2.4.3 Ca2+ sparks, puffs and sparklets 2.5 The Rubicon principle 2.5.1 Digital versus analogue cell events 2.5.2 The Ca2+ signalling toolkit 2.5.3 Amplification mechansms 2.6 Key experiments to answer key questions 2.6.1 Raising cytosolic free Ca2+ artificially 2.6.2 Measurement of free Ca2+ in live cells 2.6.3 How the Ca2+ signal is generated 2.6.4 Identifying the Ca2+ target 2.6.5 How binding of Ca2+ to its target causes the cell event 2.6.6 How the cell returns to rest 2.7 Nomenclature – how things are named 2.7.1 English and etymology 2.7.2 Organisms 2.7.3 Acronyms, cells and biochemistry 2.7.4 Genes 2.7.5 Proteins and protein sequences 2.7.6 Enzymes 2.7.7 Ion channels 2.7.8 Agonists and antagonists 2.7.9 Chemicals 2.7.10 Toxins 2.7.11 Drugs 2.7.12 Ca2+ indicators 2.7.13 Units 2.8 Model systems 2.9 Darwin, Wallace and intracellular Ca2+ 2.9.1 Natural Selection in real time 2.9.2 Small change by small change 2.10 New knowledge 2.11 Conclusions 2.12 Recommended reading Chapter 3 A century plus of intracellular calcium 3.1 Background 3.1.1 The pathway of discovery and invention for intracellular Ca2+ 3.1.2 Model systems 3.2. Why study the history of science? 3.3 The tale of three pioneers, and what followed 3.3.1 Experiments of Sydney Ringer (1835 – 1910) 3.3.2 The vision of Lewis Victor Heilbrunn (1892 – 1959) 3.3.3 Setsuro Ebashi (1922 – 2006) pioneer of intracellular Ca2+ in muscle contraction 3.4 Ca2+ as an intracellular regulator 3.4.1 Cell theory 3.4.2 Origin of the use of Ca2+ 3.4.3 Manipulation of Ca2+ 3.4.4 Measurement and location of free Ca2+ in live cells 3.4.5 Identification of the components responsible for regulating free Ca2+ inside cells 3.4.6 The discovery of plasma membrane Ca2+ pumps and transporters 3.4.7 The discovery of how Ca2+ is released from the sarco-/endo- plasmic reticulum 3.4.8 Discovery of IP3 and its receptor 3.4.9 Discovery of the ryanodine receptor 3.4.10 Discovery of store operated Ca2+ entry (SOCE) 3.4.11 Discovery of Ca2+ channels in the plasma membrane 3.4.12 Discovery of TRP channels 3.4.13 Discovery of G proteins 3.4.14 Ca2+ targets inside cells and how they work 3.4.15 Intracellular Ca2+ in plants 3.4.16 Intracellular Ca2+ in bacteria 3.4.17 Pathology of intracellular Ca2+ 3.5 Conceptual development of Ca2+ as an intracellular regulator 3.6 Summary 3.7 Recommended reading Chapter 4 How to study intracellular Ca2+ as a cell regulator 4.1 Pathway to discover the role of intracellular Ca2+ in a cell event 4.2 Manipulation of intracellular Ca2+ 4.3 Measurement of intracellular free Ca2+ 4.3.1 Absorbing dyes 4.3.2 Fluorescent Ca2+ indicators 4.3.3 Calibration of fluors 4.3.4 Ca2+-activated photoproteins 4.3.5 Calibration of Ca2+-activated photoproteins 4.3.6 Ca2+ indicators from engineered GFP 4.3.7 Other free Ca2+ indicators for whole organs and organisms 4.4 Detecting and imaging photons 4.5 Measurement of total cell Ca2+ 4.6 Calcium buffers 4.7 Measurement of Ca2+ fluxes 4.8 How to study Ca2+ channels 4.9 Discovering how the rise in cytosolic free Ca2+ occurs, and then returns to rest 4.10 Discovering the intracellular Ca2+ target, and how it works 4.11 Other ions 4.12 Summary 4.13 Recommended reading Chapter 5 How Ca2+ is regulated inside cells 5.1 Principles 5.2 How resting cells maintain their Ca2+ balance 5.3 Electrophysiology of intracellular Ca2+ 5.4 Primary stimuli that produce a cytosolic free Ca2+ signal 5.5 Plasma membrane Ca2+ channels 5.5.1 Voltage-gated Ca2+ channels 5.5.2 TRP channels 5.5.3 Receptor-activated Ca2+ channels 5.5.4 Mechanosensitive channels 5.5.5 Store-operated Ca2+ entry (SOCE) 5.5.6 Ca2+ receptor 5.6 Regulation of intracellular Ca2+ by, and within, organelles 5.6.1 Endo- and sarco- plasmic reticulum (ER/SR) 5.6.1.1 Ryanodine receptor 5.6.1.2 Inositol trisphosphate (IP3) receptor 5.6.2 Mitochondrial Ca2+ 5.6.3 Lysosomal and endosomal Ca2+ 5.6.4 Secretory vesicle Ca2+ 5.6.5 Peroxisomal Ca2+ 5.6.6 Control of Ca2+ by the Golgi 5.6.7 Nucleus and Ca2+ 5.6.8 Plant organelles and Ca2+ 5.6.9 Acidocalcisomes 5.7 Second messengers and regulation of Ca2+ signaling in the cytosol 5.8 Pore formers and intracellular Ca2+ 5.9 Gap junctions and connexins 5.10 Other ion channels and Ca2+ 5.11 Conclusions 5.12 Summary – how Ca2+ is regulated inside cells 5.13 Recommended reading Chapter 6 How Ca2+ works inside cells 6.1 Biological chemistry of Ca2+ 6.1.1 The special biological chemistry of Ca2+ 6.1.2 Key chemical properties of Ca2+ 6.1.3 Ca2+ ligands 6.1.4 Solvation 6.1.5 Problem of activity coefficients 6.1.6 Fractional Ca2+ binding after a Ca2+ signal 6.1.7 Kinetics 6.1.8 Diffusion 6.1.9 Solubility 6.2 Ca2+ binding proteins 6.2.1 Types of Ca2+ binding protein inside cells 6.2.2 Proteins with the EF-hand motif 6.2.2.1 Troponin C 6.2.2.2 Leiotonin 6.2.2.3 Calmodulin 6.2.24 Calmodulin-dependent kinases 6.2.2.5 Calcineurin 6.2.2.6 Calpains 6.2.27 Calsenilin and DREAM 6.2.2.8 Calbindin 6.2.2.9 S-100 proteins 6.2.2.110 STIM
• Edition: 1st
• Publisher Details: Hoboken, New Jersey : John Wiley & Sons, Inc
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 572.516; Intracellular calcium
• Languages: English
• ISBNs: 9781118942024; 9781118941881
• Related ISBNs: 9781118941874
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.