Cellular response to the genotoxic insult : the question of threshold for genotoxic carcinogens /: the question of threshold for genotoxic carcinogens. (2012)

• Record Type: Book
• Further Information: Note: Editors, Helmut Greim and Richard Albertini.
• Other Names: Greim, Helmut; Albertini, Richard J
• Contents: Introduction: The rationale for thresholds for genotoxic carcinogens; Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens; Dose-effect relationships of DANN-reactive liver carcinogens ; DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis; Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens; Part 3. DNA repair: Consequences and Repair of oxidative DNA damage; The plasticity of DNA damage response during cell differentiation: pathways and consequences; Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage; Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin; Different modes of cell death induced by DNA damage; Transcriptional inhibition by DNA damage as a trigger of cell death; Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication; Index
• Publisher Details: Cambridge, U.K : Royal Society of Chemistry
• Publication Date: 2012
• Extent: 1 online resource (xiv, 319 pages), illustrations
• Subjects: 616.042; Genetic toxicology; Carcinogenesis; Cellular control mechanisms; Carcinogenesis; Cellular control mechanisms; Genetic toxicology; HEALTH & FITNESS -- Diseases -- Genetic; MEDICAL -- Genetics; Carcinogenesis; Cellular control mechanisms; Genetic toxicology; Carcinogens -- toxicity; DNA Damage; Cell Death; Cell Transformation, Neoplastic; DNA Repair; Electronic books
• Languages: English
• ISBNs: 9781849732925; 1849732922
• Related ISBNs: 9781849731775
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.