Toxicokinetics and risk assessment. (©2007)

• Record Type: Book
• Further Information: Note: Edited by John C. Lipscomb, Edward V. Ohanian.
• Other Names: Lipscomb, John C; Ohanian, Edward V
• Contents: 1. Overview of approach to noncancer risk assessment / Lynne Haber -- 2. Guidance for the development of chemical-specific adjustment factors : integration with mode of action frameworks / Bette Meek and Andrew Renwick -- 3. Derivation and modeling of mechanistic data for use in risk assessment / Ronald L. Melnick -- 4. Empirically observed distributions of pharmacokinetic and pharmacodynamic variability in humans-implications for the derivation of single-point component uncertainty factors providing equivalent protection as existing reference doses / Dale Hattis and Meghan Keaney Lynch -- 5. Use of classical pharmacokinetic evaluations in drug development and safety assessment / Rakesh Dixit and Peter Ward -- 6. Considerations for applying physiologically based pharmacokinetic models in risk assessment / Chadwick Thompson, Babasaheb Sonawane, Andy Nong, and Kannan Krishnan -- 7. Considerations of design and data when developing physiologically based pharmacokinetic models / Peter J. Robinson, Jeffery M. Gearhart, Deirdre A. Mahle, Elaine A. Merrill, Teresa R. Sterner, Kyung O. Yu, and John C. Lipscomb -- 8. In silico predictions of partition coefficients for physiologically based pharmacokinetic models / Kannan Krishnan, Andy Nong, and Sami Haddad -- 9. In vitro to in vivo extrapolation of metabolic rate constants for physiologically based pharmacokinetic models / Gregory L. Kedderis -- 10. Use of physiologically based pharmacokinetic modeling to evaluate implications of human variability / P. Robinan Gentry and Harvey J. Clewell III -- 11. Developmental aspects of children's pharmacokinetics / Gary Ginsberg, Dale Hattis, and Babasaheb Sonawane -- 12. Sensitive populations and risk assessment / Michael Dourson and Daniel Drinan -- 13. Statistical issues in physiologically based pharmacokinetic modeling / Weihsueh A. Chiu -- 14. Drug development and the use of pharmacokinetics/toxicokinetics in selecting the first dose of systemically administered drugs in humans : a nonclinical perspective / Abigail Jacobs -- 15. Pharmacokinetic/physiologically based pharmacokinetic models in integrated risk information system assessments / Robert S. DeWoskin, John C. Lipscomb, Chadwick Thompson, Weihsueh A. Chiu, Paul Schlosser, Carolyn Smallwood, Jeff Swartout, Linda Teuschler, and Allan Marcus.
• Publisher Details: New York : Informa Healthcare
• Publication Date: 2007
• Copyright Date: 2007
• Extent: 1 online resource (xix, 361 pages), illustrations
• Subjects: 615.7; Health risk assessment; Pharmacokinetics; Toxicology; Pharmacokinetics; Risk Assessment -- methods; Health risk assessment; Pharmacokinetics; Risk Assessment -- methods; Risk Assessment; Toxicology; MEDICAL -- Pharmacology; Health risk assessment; Pharmacokinetics; Toxicology; Electronic books
• Languages: English
• ISBNs: 9781420019308; 1420019309; 1280732962; 9781280732966
• Related ISBNs: 0849337224; 9780849337222
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.