Modelling metabolism with Mathematica : detailed examples including erythrocyte metabolism /: detailed examples including erythrocyte metabolism. (©2003)

• Record Type: Book
• Further Information: Note: Peter J. Mulquiney, Philip W. Kuchel.
• Other Names: Mulquiney, Peter J; Kuchel, Philip W
• Contents: Introduction to Chemical Kinetics and Numerical Integration; Aims and Objectives; Complexity; Definitions; Time Courses of Reactions; Numerical Integration of Differential Equations; Predictor Corrector Methods; Conclusions; ; Elements of Enzyme Kinetics; Kinetics of Enzymic Reactions; Enzyme Inhibition; Enzyme Mechanisms; Regulatory Enzymes; ; Basic Procedures for Simulating Metabolic Systems; Introduction; Relationships between Unitary Rate Constants and Steady-State Parameters; Upper Limit of Values for Unitary Rate Constants; Realistic Enzyme Models; Deriving Expressions for Steady- State Parameters; Multiple Equilibria; pH Effects on Kinetic Parameters; A Simple Model of the Urea Cycle; Conclusions; ; Advanced Simulation of Metabolic Pathways; Introduction; Simulating the Time Dependent Behaviour of Multienzyme Systems; Using Matrix Notation in Simulating Metabolic Pathways; Generating the Stoichiometry Matrix; Determining Steady- State Concentrations; Conservation Relations; Stability of a Steady State; When Cell Volume Changes with Time; Decomposition of N and Calculation of the Link Matrix (Optional); ; Metabolic Control Analysis; Introduction; Control Coefficients; Calculation of Control Coefficients by Numerical Perturbation; Elasticity Coefficients; Response Coefficients; Internal Response Coefficients; Conclusions; ; Parameter Estimation; Introduction; Approaches to Parameter Estimation; Least Squares; Maximum a Posteriori (MAP); Parameters in Rate Equations; Parameters in Systems of Differential Equations; Optimal Parameter; Variances of Parameters; ; Model of Erythrocyte Metabolism; ; Introduction; Models of Erythrocyte Metabolism; Stoichiometry of Human Erythrocyte Metabolism; In Vivo Steady State of the Erythrocyte; Conservation of Mass Relationships; Simulating a Timecourse; ; Metabolic Control Analysis of Human Erythrocyte Metabolism; ; Introduction; Normal In Vivo Steady State; Identifying Zero Fluxes; Flux Control Coefficients; Concentration Control Coefficients; Response Coefficients and Partitioned Responses; Elasticity Coefficients; Internal Response Coefficients; Concluding Remarks; ; Note: Each chapter contains Exercises and References; ; Appendices; Rate Equation Deriver; Metabolic Control Analysis Functions; Rate Equations for Enzymes of the Human Erythrocyte; Initial Conditions and External Parameters for the Erythrocyte Model; Equation List Describing the Erythrocyte Model of Chapters 7 and 8
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2003
• Copyright Date: 2003
• Extent: 1 online resource (309 pages), illustrations
• Subjects: 572/.4/0113; Cell metabolism -- Computer simulation; Enzyme kinetics -- Computer simulation; Erythrocytes -- Computer simulation; Mathematica (Computer program language); SCIENCE -- Life Sciences -- Biochemistry; Mathematica (computerprogramma); Biochemie; Stofwisseling; Computer Simulation; Erythrocytes -- metabolism; Metabolism; Humans; Electronic books
• Languages: English
• ISBNs: 0203503937; 9780203503935; 9780849314681; 0849314682
• Related ISBNs: 0849314682
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.