Handbook of statistics in clinical oncology. (2006)

• Record Type: Book
• Further Information: Note: [edited by] John Crowley, Donna Pauler Ankerst.
• Other Names: Crowley, John, 1946-; Ankerst, Donna Pauler
• Contents: Overview of phase I trials -- Phase I and phase I/II dose finding algorithms using continual reassessment method -- Choosing a phase I design -- Pharmacokinetics in clinical oncology: statistical issues -- Practical implementation of the continual reassessment method -- Overview of Phase II clinical trials -- Designs based on toxicity and response -- Phase II trials using time-to-event endpoints -- Phase II selection designs -- On use of covariates in randomization and analysis of clinical trials -- Factorial designs with time to event endpoints -- Noninferiority trials -- Power and sample size for phase III clinical trials of survival -- Early stopping of cancer clinical trials -- Design and analysis of quality of life data -- Economic analyses alongside cancer clinical trials -- Prognostic factor studies -- Statistical methods to identify predictive factors -- Explained variation in proportional hazards regression -- Constructing prognostic groups by tree-based partitioning and peeling methods -- Clinical monitoring based on joint models for longitudinal biomarkers and event times -- Some practical considerations for analysis of spotted microarray data -- Statistical applications using DNA microarrays for cancer diagnosis and prognosis -- Profiling high-dimensional protein expression using MALDI-TOF: mass spectrometry for biomarker discovery -- Statistical approaches for high dimensional data derived from high throughput assays: a case study of protein expression levels in lung cancer -- Spatial modeling of multilocus data -- Software for genomic data -- Bayesian sensitivity analyses of confounded treatment effects -- Interpreting longitudinal studies of QOL with nonignorable dropout -- Estimation of cumulative incidence in the presence of competing risks -- Pitfalls in the design, conduct and analysis of randomized clinical trials -- Dose-intensity analysis -- Sequential randomization.
• Edition: 2nd ed
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2006
• Extent: 1 online resource (617 pages), illustrations
• Subjects: 616.99/4/0072; Cancer -- Research -- Statistical methods; Clinical trials -- Statistical methods; Neoplasms -- Therapy; Research design; Clinical trials as topic; Computational biology; Data interpretation, Statistical; MEDICAL -- Oncology; HEALTH & FITNESS -- Diseases -- Cancer; Cancer -- Research -- Statistical methods; Clinical trials -- Statistical methods; Neoplasms -- therapy; Research Design; Clinical Trials; Computational Biology; Data Interpretation, Statistical; Electronic books; Fulltext; Handbook; Internet Resource; Illustration
• Languages: English
• ISBNs: 9781420027761; 0824723392; 9780824723392
• Related ISBNs: 142002776X
• Notes: Note: Includes bibliographical references.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.