Biological performance of materials : fundamentals of biocompatibility /: fundamentals of biocompatibility. (2005)

• Record Type: Book
• Further Information: Note: Jonathan Black.
• Other Names: Black, Jonathan, 1939-
• Contents: GENERAL CONSIDERATIONS; ; Biocompatibility: Definitions and Issues; Introduction; Biological Performance; Consensus Definitions; Discussion; The Discipline of Biomaterials; Afterword: Paradigmatic Shift; ; Introduction to the Biological Environment; General Considerations; Comparison of External and Internal Conditions; Problems in Definition of the Biological Environment; Elements of the Biological Environment; Implant Life History; Preimplantation Handling Effects; ; MATERIAL RESPONSE: FUNCTION AND; DEGRADATION OF MATERIALS; IN VIVO; ; Swelling and Leaching; Introduction; Fick's Laws of Diffusion; Absorption; Examples of Undesirable Absorption; Osmotic Equilibrium; Leaching; Example of Planned Leaching: Drug Release; Effects of Swelling and Leaching; ; Corrosion and Dissolution; Chemistry of Corrosion; Classification of Reactions; The Pourbaix Diagram; The Electrochemical Series; Corrosion Rate; Potential-Current Relationships in Corrosion; Forms of Corrosion; Corrosion in Implant Applications; Engineering Variables Affecting Corrosion Rates; Corrosion Factors Peculiar to Biological Environments; Ceramic Dissolution; Polymer Dissolution; Final Remarks; ; Reactions of Biological Molecules with; Biomaterial Surfaces; Introduction; Denaturation; Organometallic Compounds; Mechanical Aspects of Interfaces; Results of Interfacial Adhesion of Molecules; Effects of Charged Interfaces and Ions; Final Comments; ; Mechanics of Materials: Deformation and Failure; Introduction; Mechanics of Materials; Elastic Modulus; Yield Strength; Fracture Strength; Final Comment; ; Friction and Wear; Introduction; Friction; Lubrication; Wear; Conclusions; ; Interpart 1; Implant Materials: Properties; Introduction; Metals; Polymers; Ceramics; Composites; ; HOST RESPONSE: BIOLOGICAL EFFECTS OF IMPLANTS; ; The Inflammatory Process; Introduction; The Inflammatory Response; Infection; Effects of Implant Degradation Products; A Final Comment; ; Coagulation and Hemolysis; Introduction; The Coagulation Cascade; Approaches to Thromboresistant Materials Development; Hemolysis; Final Comments; ; Adaptation; Introduction; Tissue Growth Strategies; Examples of Adaptation in Implant Applications; A Final Comment on Adaptation; ; In Vitro Tissue Growth and Replantation; General Considerations; What Is Tissue Engineering?; The Cell-Receptor Paradigm; Matrices and Cell Sources; Thinking Twice about Tissue Engineering; Some Final Comments; ; Allergic Foreign Body Response; Specific vs. Nonspecific Response; Mechanisms of Immune Response; Classes of Hypersensitivity Reactions; Hypersensitivity Reactions Associated with Implants; Final Comment; ; Chemical and Foreign-Body Carcinogenesis; Definitions; Chemical Carcinogenesis; Foreign Body Carcinogenesis; Nonspecific Carcinogenesis; Evidence for Implant Carcinogenesis in Humans; ; Mineral Metabolism; Introduction; Iron Metabolism; Chromium Metabolism; Human Dietary Metal Intake; ; Systemic Distribution and Excretion; Introduction; Movement of Solid Bodies; Transport of Dissolved Species; Distribution and Excretion of Dissolved Species; Final Comment; ; Effects of Degradation Products on Remote; Organ Function; Introduction; Examples of Systemic Effects; A Review of Systemic Aspects of Host Response; A Final Comment; ; Interpart 2; Implant Materials: Clinical Performance; Introduction; An Example: Total Hip Replacement; A Final Word; ; METHODS OF TESTING FOR BIOLOGICAL PERFORMANCE; ; In Vitro Test Methods; Test Strategies; In Vitro Test Types; Tissue Culture Tests; Blood Contact Tests; Final Comments; ; In Vivo Implant Models; Introduction; Test Types; A Final Comment; ; Clinical Testing of Implant Materials; Goal of Clinical Trials; Design of Clinical Trials; Conclusions from Clinical Trials; Aspects of the Decision for General Clinical Use; Final Comments; ; Standardization and Regulation of; Implant Materials; Historical Perspective; Drug Standardization Activities; Biomaterials Standardization Activities; U.S. Federal Regulation of Medical Devices and Biomaterials; Regulation of Materials for Implants; The Biomaterials Supply "Crisis"; ; Design and Selection of Implant Materials; Introduction; The Design Process; The Value of Prospective Design; ; Clinical Performance of Biomaterials; Historical Aspects; Procedures for Device Retrieval and Analysis; Common Concerns about Device Retrieval and Analysis; Proposed National Implant Data Retrieval and Analysis; Program (NIDRA); Elements of a NIDRA System; Autopsy Retrieval Studies; Concluding Remarks; ; Glossary; Introduction; Glossary; Deprecated Terms
• Edition: 4th ed
• Publisher Details: Place of publication not identified : CRC Press
• Publication Date: 2005
• Extent: 1 online resource (520 pages), (3 illustrations)
• Subjects: 617.95028; Biomedical materials; Biomedical materials -- Testing; Biocompatibility
• Languages: English
• ISBNs: 9781420057843; 1420057847
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.