Nutrigenomics. (2005)

• Record Type: Book
• Further Information: Note: Edited by Gerald Rimbach, Jürgen Fuchs, Lester Packer.
• Other Names: Rimbach, Gerald; Fuchs, Jürgen, 1957 June 28; Packer, Lester
• Contents: Cover; Series Introduction; Preface; About the Editors; Contributors; Contents; 1 Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression; WHAT IS NUTRIGENOMICS?; DO OXIDANTS AND ANTIOXIDANTS AFFECT GENE EXPRESSION?; METHODS AND APPLICATIONS IN NUTRIGENOMICS; REFERENCES; 2 Oxidative Stress and Human Genetic Variation; MANGANESE SUPEROXIDE DISMUTASE; COPPER, ZINC SUPEROXIDE DISMUTASE; THE GLUTATHIONE-S-TRANSFERASES; THE GST GENES; GLUTATHIONE-S-TRANSFERASE T1; Functional Studies of the 894G > T (Glu298Asp) Polymorphism Potential Dietary InterventionsCATALASE; NADPH OXIDASE; NADPH Oxidase Background; NADPH Polymorphisms; NADPH Polymorphisms and Health Conditions; GLUTATHIONE PEROXIDASE; MYELOPEROXIDASE; NADPH DEHYDROGENASE, QUINONE 1; NADPH Background; NADPH Polymorphisms; CONCLUSION; REFERENCES; 3 Analysis of Microarray Data; INTRODUCTION; NORMALIZATION METHODS; Per Array Normalization; Per Gene Normalizations; DATA ANALYSIS; Fold Changes in Expression Levels; Class Discovery-Unsupervised Learning Methods; Class Prediction-Supervised Learning Methods; VALIDATION OF MICROARRAY ANALYSIS Laboratory Based ValidationMICROARRAY ANALYSIS SOFTWARE; SUMMARY; REFERENCES; 4 Oxidative Stress, Gene Expression, and Lifespan; INTRODUCTION; LIFESPAN REGULATION IN C. ELEGANS Aging of C. elegans; Stress, Hormesis, and Lifespan in C. elegans; Insulin/IGF-I Signaling and Lifespan Regulation; Insulin/IGF-I Signaling Pathway and Stress Resistance; DAF-16 Transcription Target; Reproductive System and Lifespan; Nervous System and Lifespan; Mitochondrial Electron Transport and Lifespan; LIFESPAN REGULATION IN DROSOPHILA; LIFESPAN REGULATION IN MAMMALS; REPLICATIVE LIFESPAN AND OXIDATIVE STRESS CONCLUSIONREFERENCES; 5 Anti-Oxidant Modulation in Immune Function; INTRODUCTION; THE IMMUNE RESPONSE TO INFECTION INJURY AND INFLAMMATORY AGENTS; THE FUNCTION OF PRO-INFLAMMATORY CYTOKINES DURING THE NORMAL RESPONSE TO INFECTION AND INJURY; ADVERSE EFFECTS OF PRO-INFLAMMATORY CYTOKINES; ANTI-OXIDANT DEFENSES ARE INTERLINKED AND INTERDEPENDENT; A DECLINE IN ANTI-OXIDANT DEFENSES AND INCREASED OXIDANT DAMAGE FOLLOWS INFECTION AND INJURY; AGING INCREASES OXIDATIVE AND INFLAMMATORY STRESS; Mechanisms Underlying Low-Grade Inflammation During Aging MECHANISMS OF THE EFFECTS OF OXIDANTS AND ANTI-OXIDANTS ON INFLAMMATION AND IMMUNE FUNCTIONEFFECTS OF ANTI-OXIDANTS ON IMMUNE FUNCTION Effects of Vitamin E; Ascorbic Acid and Immune Function; Glutathione and Immune Function; EFFECTS OF SUBSTANCES THAT ACT AS PRECURSORS FOR GSH OR COFACTORS IN ENZYME PATHWAYS ASSOCIATED WITH GSH ON IMMUNE FUNCTION Effects of Precursors of GSH on Immune Function; Effects of Vitamin B6 on Immune Function; Effects of Folic Acid on Immune Function; Taurine and Immune Function; CONCLUSIONS; REFERENCES
• Publisher Details: Boca Raton : Taylor & Francis
• Publication Date: 2005
• Extent: 1 online resource (xvii, 482 pages), illustrations
• Subjects: 612.3; Nutrition -- Genetic aspects; Nutrient interactions; Genetic regulation; Functional genomics; Nutritional physiological phenomena; Antioxidants; Gene expression; Oxidants; Oxidative stress -- Genetics; MEDICAL -- Nutrition; Functional genomics; Genetic regulation; Nutrient interactions; Nutrition -- Genetic aspects; Genomics; Nutritional Physiological Phenomena; Antioxidants; Gene Expression; Oxidants; Oxidative Stress -- genetics; Electronic books; Electronic books
• Languages: English
• ISBNs: 9781420028096
• Related ISBNs: 142002809X; 9780824726638; 0824726634
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.