Modern neurosurgery : clinical translation of neuroscience advances /: clinical translation of neuroscience advances. (©2005)
- Record Type:
- Book
- Title:
- Modern neurosurgery : clinical translation of neuroscience advances /: clinical translation of neuroscience advances. (©2005)
- Main Title:
- Modern neurosurgery : clinical translation of neuroscience advances
- Further Information:
- Note: Edited by Dennis A. Turner.
- Other Names:
- Turner, Dennis A
- Contents:
- Front cover; Foreword and Scope; Acknowledgments; Editor; Contributors; Table of Contents; 1; Neuroscience Hypotheses and Translation into Neurosurgery Practice; 1.1 Introduction; 1.1.1 Concept of Translational Neuroscience; 1.1.2 Translational Neurosurgery versus Translational Neuroscience; 1.1.3 Examples of Translational Products; 1.2 Categories of Neurosurgery Advances; 1.3 Critical Questions in Translational Neurosurgery; 1.3.1 When Is Preclinical Data Sufficient to Proceed to Human Experimentation?; 1.3.2 Who Is Involved with Translational Neurosurgery? 1.3.3 Mechanisms of Translational Neurosurgery: University and Corporate Involvement1.3.4 Device Development Process; 1.3.5 Guidelines for Efficacious Treatment Schemes; 1.4 Outline of Topics of Neurosurgery Advances; 1.5 Levels of Nervous System Functioning: Cellular to Systems; 1.6 Conclusions; References; 2; Clinical Prospects for Neural Grafting Therapy for Cortical Lesions; 2.1 Introduction; 2.2 Graft Cell Integration: Preclinical Studies; 2.2.1 Graft Cell Labeling; 2.2.2 Graft Cell Survival; 2.2.3 Graft Cell Migration and Dispersion; 2.2.4 Synaptic Graft-Host Interactions. 2.2.5 Preclinical Graft Cell Sources2.3 Clinical Contexts; 2.3.1 Cortical Lesions: Early Postlesion Grafting; 2.3.2 Cortical Lesions: Late Postlesion Grafting; 2.3.3 Neural Grafts for Treatment of Epilepsy; 2.3.4 Neural Grafts for Treatment of Stroke; 2.3.5 Neural Grafts for Treatment of Severe Head Injury; 2.4 Clinically Appropriate Graft CellFront cover; Foreword and Scope; Acknowledgments; Editor; Contributors; Table of Contents; 1; Neuroscience Hypotheses and Translation into Neurosurgery Practice; 1.1 Introduction; 1.1.1 Concept of Translational Neuroscience; 1.1.2 Translational Neurosurgery versus Translational Neuroscience; 1.1.3 Examples of Translational Products; 1.2 Categories of Neurosurgery Advances; 1.3 Critical Questions in Translational Neurosurgery; 1.3.1 When Is Preclinical Data Sufficient to Proceed to Human Experimentation?; 1.3.2 Who Is Involved with Translational Neurosurgery? 1.3.3 Mechanisms of Translational Neurosurgery: University and Corporate Involvement1.3.4 Device Development Process; 1.3.5 Guidelines for Efficacious Treatment Schemes; 1.4 Outline of Topics of Neurosurgery Advances; 1.5 Levels of Nervous System Functioning: Cellular to Systems; 1.6 Conclusions; References; 2; Clinical Prospects for Neural Grafting Therapy for Cortical Lesions; 2.1 Introduction; 2.2 Graft Cell Integration: Preclinical Studies; 2.2.1 Graft Cell Labeling; 2.2.2 Graft Cell Survival; 2.2.3 Graft Cell Migration and Dispersion; 2.2.4 Synaptic Graft-Host Interactions. 2.2.5 Preclinical Graft Cell Sources2.3 Clinical Contexts; 2.3.1 Cortical Lesions: Early Postlesion Grafting; 2.3.2 Cortical Lesions: Late Postlesion Grafting; 2.3.3 Neural Grafts for Treatment of Epilepsy; 2.3.4 Neural Grafts for Treatment of Stroke; 2.3.5 Neural Grafts for Treatment of Severe Head Injury; 2.4 Clinically Appropriate Graft Cell Sources; 2.4.1 Embryonic Neural Cells; 2.4.2 Cultured Cell Lines; 2.4.3 Non-Neural Cells; 2.4.4 Pluripotent Progenitor and Stem Cells; 2.5 Side Effects of Neural Grafts; 2.6 Clinical Applicability and Challenges in Translation; References; 3. Advances in Treatment of Spinal Cord and Peripheral Nerve Injury3.1 Introduction; 3.2 Spinal Cord Neuroprotection; 3.2.1 Maturation of Spinal Cord Injury; 3.2.2 Secondary Neuroprotection Treatment Schemes; 3.3 Spinal Cord Regeneration; 3.3.1 Enhancement of Axonal Regrowth; 3.3.2 Cellular or Inert Bridges and Neural Grafting; 3.4 Rehabilitation; 3.5 Neuroprosthetics; 3.6 Combination Therapies; 3.7 Peripheral Nerve Repair; 3.7.1 Nerve Guide Tubes; 3.7.2 Enhancement of Specificity of Regeneration; 3.8 Conclusions; References; 4. Cellular Brain Ischemia and Stroke: Neuroprotection, Metabolism, and New Strategies for Brain Recovery4.1 Introduction; 4.2 Types of Strokes and Cerebral Ischemia Events; 4.3 Cellular Consequences of Stroke; 4.4 Problems in Translation of Stroke Treatments from Bench to Bedside; 4.4.1 Animal Models of Ischemic Stroke; 4.4.2 Time Windows of Treatment; 4.4.3 Early vs. Late Outcome Definition; 4.4.4 Regional Differences in Target Areas of Brain; 4.4.5 Pharmacokinetics, Safety Issues, and Appropriate Dosing; 4.4.6 Clinical Outcome Measures and Statistical Issues with Clinical Trials. … (more)
- Publisher Details:
- Boca Raton : CRC Press
- Publication Date:
- 2005
- Copyright Date:
- 2005
- Extent:
- 1 online resource (323 pages), illustrations (some color)
- Subjects:
- 617.4/8
Nervous system -- Surgery
Neurosurgery -- Trends
Neurosurgical procedures -- Trends
MEDICAL -- Surgery -- Neurosurgery
Nervous system -- Surgery
Neurosurgery -- trends
Neurosurgical Procedures -- trends
Electronic books - Languages:
- English
- ISBNs:
- 0203503996
9780203503997 - Related ISBNs:
- 0849314828
9780849314827 - Notes:
- Note: Includes bibliographical references and index.
Note: Print version record. - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.163412
- Ingest File:
- 01_080.xml