Protein therapeutics. (2017)

• Record Type: Book
• Further Information: Note: Tristan Vaughan [and five others].
• Authors: Vaughan, Tristan
• Editors: Vaughan, Tristan; Osbourn, Jane; Jallal, Bahija; Mannhold, Raimund; Folkers, Gerd; Buschmann, Helmut
• Contents: Contents to Volume 1 Preface XVII A Personal Foreword XXI Acknowledgements XXIII Part I Introduction to Protein Therapeutics: Past and Present 1 1 Early Recombinant Protein Therapeutics 3; Pierre De Meyts 2 Evolution of Antibody Therapeutics 25; Hervé Watier and Janice M. Reichert Part II Antibodies: The Ultimate Scaffold for Protein Therapeutics 51 3 Human Antibody Structure and Function 53; Ponraj Prabakaran and Dimiter S. Dimitrov 4 Antibodies from Other Species 85; Melissa L. Vadnais, Michael F. Criscitiello, and Vaughn V. Smider Part III Discovery and Engineering of Protein Therapeutics 113 5 Human Antibody Discovery Platforms 115; William R. Strohl 6 Beyond Antibodies: Engineered Protein Scaffolds for Therapeutic Development 161; Nishant K. Mehta and Jennifer R. Cochran 7 Protein Engineering: Methods and Applications 189; Claire Dobson 8 Bispecifics 229; Jijie Gu, Andrew McCluskey, and Tariq Ghayur 9 Antibody–drug Conjugates (ADCs) 271; Dr Philip W. Howard Contents to Volume 2 Preface XVII A Personal Foreword XXI Acknowledgements XXIII Part IV Physiological and Manufacturing Considerations for Biologics 311 10 Pharmacokinetics of Therapeutic Proteins 313; Zheng Lu, Jennifer Sheng, and Wenhui Zhang References 334 11 Safety Considerations for Biologics 341; Maggie Dempster, Lucinda R. Weir, and Rajni S. Fagg 12 Immunogenicity of Biologics 387; Matthew P. Baker, Timothy D. Jones, and Paul Chamberlain 13 Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture 423; Adam J. Brown, Devika Kalsi, Alejandro Fernandez-Martell, Joe Cartwright, Nicholas O. W. Barber, Yash D. Patel, Richard Turner, Claire L. Bryant, Yusuf B. Johari, and David C. James Abbreviations 450 References 452 14 Stability, Formulation, and Delivery of Biopharmaceuticals 469; Hanns-Christian Mahler and Andrea Allmendinger Part V Clinical Applications 493 15 Protein Therapeutics in Autoimmune and Inflammatory Diseases 495; Anthony J. Coyle and Leigh S. Zawel References 511 16 Antibody-Based Therapeutics in Oncology 521; Paul A. Moore, Ross La Motte-Mohs, Jonathan C. Li, and Gurunadh R. Chichili 17 Protein Therapeutics in Respiratory Medicine 587; Rahul Shrimanker and Ian D. Pavord 18 Antibodies for the Prevention, Treatment, and Preemption of Infectious Diseases 611; Steve Projan 19 Rescue Therapies 621; Stephan Glund 20 Biosimilars 645; Jun Wang Part VI Future Horizons 661 21 Future Horizons and New Target Class Opportunities 663; Herren Wu, Carl Webster, Judy Paterson, Sandrine Guillard, Ron Jackson, and Ralph Minter References 690 Index 701
• Edition: 1st
• Publisher Details: Weinheim : Wiley-VCH
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 615.3; Protein drugs; Proteins -- Therapeutic use
• Languages: English
• ISBNs: 9783527699148; 9783527699131; 9783527699155
• Related ISBNs: 9783527340866
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.