Targeted Biomarker Quantitation by LC-MS. (2017)

• Record Type: Book
• Further Information: Note: Naidong Weng, Wenying Jian.
• Editors: Weng, Naidong; Jian, Wenying
• Contents: List of Contributors Preface Abbreviations Chapter Authors Part 1. Overview 1. Overview of Targeted Quantitation of Biomarkers and Its Application 2. Translational Application of Biomarkers 3. Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach 4. Modern Liquid Chromatography and Mass Spectrometry for Targeted Biomarker Quantitation 5. Comparison between LC-MS and Ligand Binding Assay Approaches for Biomarker Quantification 6. Sample Preparation Methods for Targeted Biomarker Quantification by LC-MS 7. Overcome the Endogenous Levels in Biomarker Quantitation Using LC-MS Part 2. Challenges and Approaches 8. Sample Collection for Targeted Biomarker Quantitation by LC-MS 9. Nonspecific Binding in LC–MS Bioanalysis 10. Strategies for Improving Sensitivity for Targeted Quantitation by LC-MS 11. Strategies to Improve Specificity for Targeted Biomarker Quantitation by LC-MS 12. Biomarker Quantitation Using Relative Approaches 13. Targeted Quantification of Amino Acid Biomarkers Using LC-MS Part 3. Applications 14. Targeted Quantification of Peptide Biomarkers – A Case Study of Amyloid Peptides 15. Targeted Protein Biomarker Quantitation by LC-MS 16. Glycoprotein Biomarkers 17. Targeted Lipid Biomarker Quantitation Using Liquid Chromatography – Mass Spectrometry (LC-MS) 18. Targeted LC-MS Quantification of Androgens and Estrogens for Biomarker Development 19. Steroid Biomarkers 20. Bile Acids as Biomarkers 21. Biomarkers for Vitamin Status and Deficiency – LC-MS Based Approach 22. Quantitation of acyl-coenzyme A thioesters as metabolic biomarkers 23. Neurotransmitter Biomarkers 24. Targeted Quantification of Carbohydrate Biomarkers Using LC-MS 25. Nucleoside/Nucleotide Biomarkers 26. LC-MS of RNA Biomarkers
• Edition: 1st
• Publisher Details: Wiley
• Publication Date: 2017
• Extent: 1 online resource (464 pages)
• Subjects: 572.36
• Languages: English
• ISBNs: 9781119413059
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.