Drug-drug interactions. (2001)

• Record Type: Book
• Further Information: Note: Edited by A. David Rodrigues.
• Other Names: Rodrigues, A. David
• Contents: 1. Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- 2. In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kennerh R. Korzekwa -- 3. Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones -- 4. Review of human UDP-Glucuronosyltransferases and their role in drug-drug interactions /9 Rory P. Remmei -- 5. Drug-drug interactions involving the membrane transport process / Hiroyuki Kttsuhara and Yuicfii Sugiyama -- 6. In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- 7. In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs / Ajay Madan [and others] -- 8. The role of P-Glycoprotein in drug disposition : significance to drug development / Matthew D. Troutman [and others] -- 9. The role of the gut mucosa in metabolically based drug- drug interactions / Kenneth E. Thummel and Danny D. Shen -- 10. Mechanism-based inhibition of human cytochromes P45Q : in vitro kinetics and in vitro-in vivo correlations / David R. Jones and Stephen D. Hall -- 11. Prediction of metabolic drug interactions : quantitative or qualitative? / Jiunn H. Lin and Paid G. Pearson -- 12. In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- 13. Molecular modeling approaches to predicting drug metabolism and toxicity / Anton M. ter Laak, Marcel J. de Groat, and Nico P.E. Vermenlen -- 14. Development of a metabolic drug interaction database at the University of Washington / Sonia P. Carbon [and others] -- 15. Drug-drug interactions : clinical perspective / David J. Greenblatt and Lisa L. van Moltke -- 16. Drug-drug interactions : toxicological perspectives / Sidney D. Nelson -- 17. An integrated approach to assessing drug-drug interactions : a regulatory perspective / Shiew-Mei Huang [and others] -- 18. Drug-drug interactions : marketing perspectives / Kevin J. Petty and Jose José M. Vega.
• Publisher Details: Place of publication not identified : CRC Press
• Publication Date: 2001
• Extent: 1 online resource (678 pages)
• Subjects: 615/.7045; Drug Interactions; Pharmacokinetics; Drug interactions; Pharmacokinetics; Interactions médicamenteuses; Pharmacocinétique; Drug interactions; Pharmacokinetics; Médicaments -- Interaction; Pharmacocinétique; Arzneimittelwechselwirkung
• Languages: English
• ISBNs: 9781420002430; 1420002430
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.