Therapeutic peptides and proteins : formulation, processing, and delivery systems /: formulation, processing, and delivery systems. (2006)

• Record Type: Book
• Further Information: Note: Ajay K. Banga.
• Other Names: Banga, Ajay K
• Contents: Pharmaceutical Biotechnology: The Arrival of Recombinant Proteins; What is Biotechnology; The Biotechnology Industry; Regulatory Aspects of Biotechnology-Derived Drugs; Immunogenicity of Proteins; Structure-Based Drug Design; Conclusions; Structure and Analysis of Therapeutic Peptides and Proteins; Amino Acids: Building Blocks of Proteins; Structure of Peptides and Proteins; Protein Conformation and Other Structural Features; Analytical Methods; Conclusions; Stability of Therapeutic Peptides and Proteins; Introduction; Physical Instability; Chemical instability; Well-Characterized Products and Comparability Protocols; Conclusions; Preformulation and Formulation of Therapeutic Peptides and Proteins; Introduction; Preformulation Studies; Formulation Development; Pharmaceutical Excipients in Formulations; Aggregation in Protein Formulations; Novel Formulation Approaches ; Accelerated Stability Testing; Statistical Design for Formulation Development; Conclusions; Lyophilization, Pharmaceutical Processing, and Handling of Therapeutic Peptides and Proteins; Introduction; Protein Destabilization Induced by Pharmaceutical Processing; Lyophilization as a Pharmaceutical Process; Alternative Pharmaceutical Processes; Handling of Therapeutic Peptides and Proteins; Conclusions; Parenteral Controlled Delivery and Pharmacokinetics of Therapeutic Peptides and Proteins; Introduction; Pharmacokinetics of Peptide and Protein Drugs; Polymers Used for Controlled Delivery of Peptides and Proteins; Parenteral Controlled Release Systems; Innovations in Parenteral Administration of Proteins; Examples of Protein Pharmacokinetics; Conclusions; Oral Delivery of Peptide and Protein Drugs; Introduction; Barriers to Protein Absorption and Pathways of Penetration; Approaches to Improve Oral Delivery; Methods to Study Oral Absorption; Oral Immunization; Conclusions; Transdermal and Topical Delivery of Therapeutic Peptides and Proteins; Introduction; Skin Structure; Approaches to Enhance Transdermal Peptide Delivery; Iontophoresis; Topical Delivery of Therapeutic Peptides and Proteins; Conclusions; Pulmonary and Other Mucosal Delivery of Therapeutic Peptides and Proteins; Introduction; Pulmonary Delivery; Nasal Delivery; Rectal Delivery; Buccal Delivery; Ocular Delivery; Comparative Evaluation of Mucosal Routes; Conclusions; Recombinant Protein Subunit Vaccines and Delivery Methods; Introduction; Immunology Relevant to Vaccines; Routes of Administration; Delivery Approaches for Administration of Vaccines; Case example: Hepatitis B; Future Outlook and Regulatory Status; Conclusions
• Edition: 2nd ed
• Publisher Details: Boca Raton, FL : CRC/Taylor & Francis
• Publication Date: 2006
• Extent: 1 online resource (354 pages), illustrations
• Subjects: 615/.3; Protein drugs; Peptides -- Pharmacology; Peptides -- Therapeutic use; Drug administration routes; MEDICAL -- Pharmacology; Protein drugs; Peptides -- pharmacology; Peptides -- therapeutic use; Drug Administration Routes; Proteins -- pharmacology; Proteins -- therapeutic use; Electronic books
• Languages: English
• ISBNs: 1420039830; 9781420039832
• Related ISBNs: 0849316308; 9780849316302
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.