Nutrient-gene interactions in cancer. (2006)

• Record Type: Book
• Further Information: Note: Edited by Sang-Woon Choi, Simonetta Friso.
• Other Names: Choi, Sang-Woon; Friso, Simonetta
• Contents: Front cover; Preface; About the Editors; Contributors; Table of Contents; Chapter 1; Nutrient and Gene Interactions in Cancer; 1.1 Introduction; 1.2 Types of Epidemiological Studies; 1.3 Ecological Studies; 1.4 Analytic Epidemiology: Case-Control and Prospective Cohort Studies; 1.5 Confounding; 1.6 Randomized Intervention Trials; 1.7 The Combined Study of Genetics and Nutrition in Epidemiological Studies; 1.8 Public Health Implications of Nutrient-Environment Interactions; 1.9 Summary and Conclusion; References; Chapter 2; Candidate Mechanisms for Interactions between Nutrients and Genes 2.1 Introduction2.2 Nutritional Modulation of Gene Expression; 2.2.1 Effects on Transcription; 2.2.1.1 Cis-Acting Elements; 2.2.1.2 Transcription Factors Are Trans-Acting Factors; 2.2.1.3 Epigenetic Modifications; 2.2.2 Posttranscriptional Control of Gene Expression; 2.2.3 Posttranslational Modification; 2.3 Impact of Genotype on Responses to Nutrients; 2.4 Mechanisms by which Food Constituents May Influence Carcinogenesis; 2.4.1 Nutrition, Inflammation, and Cancer Risk; 2.4.1.1 Intestinal Bacteria; 2.4.1.2 Obesity; 2.5 Nutritional Modulation of DNA Damage and Repair 2.6 Developmental Origins of Cancer2.7 Concluding Remarks; References; Chapter 3; Biomarkers for Nutrient-Gene Interactions; 3.1 Dietetic Modification of Cancer Risk and Relevant Biomarkers; 3.1.1 Fruit, Vegetables, and Decreased Cancer Risk: Putative Mechanisms; 3.1.1.1 Oxidative DNA Damage (8-OHdG); 3.1.1.2 Bulky DNA Adducts and Mutagen Sensitivity; 3.1.2 High Meat Consumption and Increased Risk of Colorectal Cancer; 3.1.2.1 Heterocyclic Aromatic Amines (HAA) and HAA Adducts; 3.1.2.2 N-Nitroso Compounds; 3.1.3 Single Nutrients: Folate 3.1.3.1 Evidence and Strength of Association from Cohort Studies3.1.3.2 Alcohol and Folate; 3.2 Genetic Susceptibility; 3.3 Combination of Genes and Pathways; 3.4 Fruit, Vegetables, and Decreased Cancer Risk; 3.4.1 Hypothesis I: Role of GSTs; 3.4.2 Hypothesis II: Repair of Oxidative DNA Damage; 3.5 High Meat Consumption and Increased Risk of Colorectal Cancers; 3.6 Folate; 3.6.1 Folate and MTHFR Polymorphisms; 3.6.2 Folate and Promoter Methylation; 3.7 Conclusion; Acknowledgments; Abbreviations; References; Chapter 4 Interaction between Folate and Methylene- tetrahydrofolate Reductase Gene in Cancer4.1 Introduction; 4.2 Folate and the Risk of Colorectal Cancer; 4.3 Importance of Folate and MTHFR Gene in One-Carbon Metabolism; 4.4 Interaction between Folate and MTHFR Gene; 4.4.1 Characteristics of MTHFR Gene Polymorphisms; 4.4.2 Mechanism of Folate and MTHFR Gene Interaction; 4.4.3 Effect of Folate and MTHFR Gene Interaction on DNA Methylation; 4.5 Interaction between Folate and MTHFR Gene in Colorectal Carcinogenesis; 4.6 Interaction between Folate and MTHFR Gene in Other Neoplastic Diseases
• Publisher Details: Boca Raton, FL : CRC/Taylor & Francis
• Publication Date: 2006
• Extent: 1 online resource (281 pages), illustrations
• Subjects: 616.99/4042; Cancer -- Nutritional aspects; Gene expression; Genetic regulation; Neoplasms -- Genetics; Epidemiologic studies; Genes -- Physiology; Nutritional physiological phenomena; MEDICAL -- Oncology; HEALTH & FITNESS -- Diseases -- Cancer; Cancer -- Nutritional aspects; Gene expression; Genetic regulation; Gene Expression Regulation; Neoplasms -- genetics; Epidemiologic Studies; Genes -- physiology; Nutritional Physiological Phenomena; Electronic books; Electronic books
• Languages: English
• ISBNs: 1420004840; 9781420004847; 9780849332296
• Related ISBNs: 084933229X
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.