Cardiovascular toxicology. (2001)

• Record Type: Book
• Further Information: Note: Edited by Daniel Acosta, Jr.
• Other Names: Acosta, Daniel, 1945-
• Contents: ""CONTENTS""; ""CONTRIBUTORS""; ""SERIES PREFACE""; ""PREFACE""; ""Part I INTRODUCTION""; ""1 CARDIOVASCULAR TOXICOLOGY""; ""Introductory remarks""; ""Cardiac myocyte growth and programmed death: emerging areas for research in cardiovascular toxicology""; ""Overview""; ""In vitro model systems for studying cardiac myocyte hypertrophic growth and apoptotic death""; ""Neonatal rat cardiac myocyte cultures""; ""Adult rat cardiac myocyte cultures""; ""Cardiac myocyte growth""; ""Defining cardiac myocyte hypertrophy in vitro""; ""Hypertrophic stimuli""; ""Hypertrophic signaling pathways"" ""MAPK pathways""""Other pathways""; ""Gene expression during cardiac myocyte hypertrophy""; ""Immediate-early gene expression""; ""Late gene expression""; ""Hypertrophic growth""; ""Possibilities for cardiac myocyte growth in response to toxicants or toxicant-induced injury""; ""Summary""; ""Cardiac myocyte apoptosis""; ""Cardiac myocyte apoptotic stimuli""; ""Targets for apoptosis""; ""Apoptotic signaling pathways""; ""Bcl-2 family""; ""p53""; ""c-Myc""; ""Effectors of apoptosis""; ""Toxicant-induced cardiac myocyte apoptosis""; ""Conclusions""; ""Acknowledgment""; ""References"" ""Part II METHODS""""2 ACUTE AND CHRONIC EVALUATION OF THE CARDIOVASCULAR TOXICITY OF DRUGS""; ""Pharmacologic profiling""; ""In vivo parameter evaluations in standard studies""; ""Electrocardiograms""; ""Blood pressure and heart rate""; ""Flow measurement techniques""; ""Magnetic resonance imaging""; ""Clinical signs/observations""; ""Clinical pathology""; ""Electrolytes""; ""Osmolality and acid-base balance""; ""Enzymes""; ""Creatine phosphokinase""; ""Lactate dehydrogenase""; ""Serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase""; ""Other proteins""; ""Lipids"" ""Pathology""""Cardiomyopathy""; ""Cardiac hypertrophy""; ""Vasculature""; ""Hemorrhage""; ""Animal models""; ""In vitro models and their use""; ""Summary""; ""References""; ""3 EVALUATION OF IN VITRO CYTOTOXICITY MODELING""; ""Overview""; ""Credence of a model""; ""Problems in defining criteria for cytotoxicity assessment""; ""Approaches for modeling cytotoxicity""; ""Primary heart cell cultures for cytotoxicity screening""; ""Neonatal cardiac myocytes""; ""Adult cardiac myocytes""; ""Cytotoxicity assessment""; ""Sarcolemma breakdown""; ""Dye exclusion assays""; ""Cytosolic enzyme release"" ""Evaluation of data from permeability assays""""Mechanistic investigations""; ""Contractile activity""; ""Cellular energy supply""; ""SUCCINATE DEHYDROGENASE ACTIVITY (MTT ASSAY)""; ""MITOCHONDRIAL MEMBRANE POTENTIAL""; ""HYDROGEN ION GRADIENTS""; ""Calcium homeostasis""; ""Summary and conclusions""; ""Acknowledgments""; ""References""; ""4 MONITORING OF CARDIOVASCULAR DYNAMICS IN CONSCIOUS ANIMALS""; ""Large animal techniques for measurement of cardiovascular parameters""; ""Arterial and ventricular pressures""; ""Blood flow measurements""; ""Electromagnetic flow technique""
• Edition: 3rd ed
• Publisher Details: London New York : Taylor & Francis Publishers
• Publication Date: 2001
• Extent: 1 online resource (xv, 589 pages)
• Subjects: 616.1/07; Cardiovascular system -- Diseases; Cardiovascular system -- Diseases -- Treatment; Cardiovascular system -- Diseases; Cardiovascular toxicology; Cardiovascular system -- Diseases; Cardiovascular system -- Diseases -- Treatment; Electronic books
• Languages: English
• ISBNs: 0203361458; 9780203361450; 0415248698; 9780415248693; 1560328053; 9781560328056
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.